Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.

An octacosapeptide that we named pro-somatostatin has been isolated from acid extracts of porcine hypothalami and found to have the amino acid sequence Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys. This octacosapeptide possesses high...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Schally, A V, Huang, W Y, Chang, R C, Arimura, A, Redding, T W, Millar, R P, Hunkapiller, M W, Hood, L E
Formato: Artículo
Lenguaje:en
Publicado: 1980
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC349869/
https://ncbi.nlm.nih.gov/pubmed/6107906
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id pubmed-349869
record_format dspace
spelling pubmed-3498692004-03-13 Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus. Schally, A V Huang, W Y Chang, R C Arimura, A Redding, T W Millar, R P Hunkapiller, M W Hood, L E Proc Natl Acad Sci U S A Research Article An octacosapeptide that we named pro-somatostatin has been isolated from acid extracts of porcine hypothalami and found to have the amino acid sequence Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys. This octacosapeptide possesses high somatotropin (growth hormone) and prolactin release-inhibiting activity in vitro. It also crossreacts strongly with antisera generated against the somatostatin tetradecapeptide. This octacosapeptide is most likely a precursor (pro-hormone) of somatostatin in the hypothalamus. The existence of still larger molecular size precursors of somatostatin was also observed. 1980-08 /pmc/articles/PMC349869/ /pubmed/6107906 Text en
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Research Article
spellingShingle Research Article
Schally, A V
Huang, W Y
Chang, R C
Arimura, A
Redding, T W
Millar, R P
Hunkapiller, M W
Hood, L E
Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.
description An octacosapeptide that we named pro-somatostatin has been isolated from acid extracts of porcine hypothalami and found to have the amino acid sequence Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys. This octacosapeptide possesses high somatotropin (growth hormone) and prolactin release-inhibiting activity in vitro. It also crossreacts strongly with antisera generated against the somatostatin tetradecapeptide. This octacosapeptide is most likely a precursor (pro-hormone) of somatostatin in the hypothalamus. The existence of still larger molecular size precursors of somatostatin was also observed.
author Schally, A V
Huang, W Y
Chang, R C
Arimura, A
Redding, T W
Millar, R P
Hunkapiller, M W
Hood, L E
author_facet Schally, A V
Huang, W Y
Chang, R C
Arimura, A
Redding, T W
Millar, R P
Hunkapiller, M W
Hood, L E
author_sort Schally, A V
title Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.
title_short Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.
title_full Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.
title_fullStr Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.
title_full_unstemmed Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.
title_sort isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.
publishDate 1980
url https://ncbi.nlm.nih.gov/pmc/articles/PMC349869/
https://ncbi.nlm.nih.gov/pubmed/6107906
_version_ 1759381823270420480

Ejemplares similares