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Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington’s disease
Oxidative damage and mitochondrial dysfunction are implicated in aging and age-related neurodegenerative diseases, including Huntington’s disease (HD). Many naturally occurring antioxidants have been tested to correct for deleterious effects of reactive oxygen species, but often they lack specificit...
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| Format: | Artigo |
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| Jezik: | en |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3513647/ https://ncbi.nlm.nih.gov/pubmed/23122961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.10.001 |
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