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Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation
High affinity antibodies are generated in mice and humans by means of somatic hypermutation (SHM) of variable (V) regions of Ig genes. Mutations with rates of 10(−5)–10(−3) per base pair per generation, about 10(6)-fold above normal, are targeted primarily at V-region hot spots by unknown mechanisms...
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| Format: | Artikel |
| Sprache: | en |
| Veröffentlicht: |
The National Academy of Sciences
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC35453/ https://ncbi.nlm.nih.gov/pubmed/11427727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.141222198 |
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