Mechanism of Inhibition of Vaccinia Virus Replication in Adenovirus-Infected HeLa Cells

The ability of vaccinia virus to replicate in HeLa cells which had been previously infected with adenovirus type 2 (Ad2) was studied in order to gain insight into the mechanism by which adenovirus inhibits the expression of host cell functions. Vaccinia virus was employed in these studies because it...

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Hlavní autoři: Giorno, Ralph, Kates, J. R.
Médium: Článek
Jazyk:en
Vydáno: 1971
Témata:
Animal Viruses
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC356100/
https://ncbi.nlm.nih.gov/pubmed/5111060
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spelling pubmed-3561002004-03-04 Mechanism of Inhibition of Vaccinia Virus Replication in Adenovirus-Infected HeLa Cells Giorno, Ralph Kates, J. R. J Virol Animal Viruses The ability of vaccinia virus to replicate in HeLa cells which had been previously infected with adenovirus type 2 (Ad2) was studied in order to gain insight into the mechanism by which adenovirus inhibits the expression of host cell functions. Vaccinia virus was employed in these studies because it replicates in the cytoplasm, whereas Ad2 replicates in the nucleus of the cell. It was found that vaccinia deoxyribonucleic acid (DNA) synthesis is greatly inhibited in adeno-preinfected HeLa cells provided that vaccinia superinfection does not occur before 18 hr after adeno infection. The inhibition of vaccinia DNA synthesis can be traced to an inhibition of vaccinia protein synthesis and viral uncoating. Vaccinia ribonucleic acid (RNA) synthesis is not inhibited in adeno-preinfected cells, but the vaccinia RNA does not become associated with polysomes. 1971-02 /pmc/articles/PMC356100/ /pubmed/5111060 Text en Copyright © 1971 American Society for Microbiology
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Animal Viruses
spellingShingle Animal Viruses
Giorno, Ralph
Kates, J. R.
Mechanism of Inhibition of Vaccinia Virus Replication in Adenovirus-Infected HeLa Cells
description The ability of vaccinia virus to replicate in HeLa cells which had been previously infected with adenovirus type 2 (Ad2) was studied in order to gain insight into the mechanism by which adenovirus inhibits the expression of host cell functions. Vaccinia virus was employed in these studies because it replicates in the cytoplasm, whereas Ad2 replicates in the nucleus of the cell. It was found that vaccinia deoxyribonucleic acid (DNA) synthesis is greatly inhibited in adeno-preinfected HeLa cells provided that vaccinia superinfection does not occur before 18 hr after adeno infection. The inhibition of vaccinia DNA synthesis can be traced to an inhibition of vaccinia protein synthesis and viral uncoating. Vaccinia ribonucleic acid (RNA) synthesis is not inhibited in adeno-preinfected cells, but the vaccinia RNA does not become associated with polysomes.
author Giorno, Ralph
Kates, J. R.
author_facet Giorno, Ralph
Kates, J. R.
author_sort Giorno, Ralph
title Mechanism of Inhibition of Vaccinia Virus Replication in Adenovirus-Infected HeLa Cells
title_short Mechanism of Inhibition of Vaccinia Virus Replication in Adenovirus-Infected HeLa Cells
title_full Mechanism of Inhibition of Vaccinia Virus Replication in Adenovirus-Infected HeLa Cells
title_fullStr Mechanism of Inhibition of Vaccinia Virus Replication in Adenovirus-Infected HeLa Cells
title_full_unstemmed Mechanism of Inhibition of Vaccinia Virus Replication in Adenovirus-Infected HeLa Cells
title_sort mechanism of inhibition of vaccinia virus replication in adenovirus-infected hela cells
publishDate 1971
url https://ncbi.nlm.nih.gov/pmc/articles/PMC356100/
https://ncbi.nlm.nih.gov/pubmed/5111060
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