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8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation
The refractoriness of acute promyelocytic leukemia (APL) with t(11;17)(q23;q21) to all-trans retinoic acid (ATRA)-based therapy concerns clinicians and intrigues basic researchers. By using a murine leukemic model carrying both promyelocytic leukemia zinc finger/retinoic acid receptor-α (PLZF/RARα)...
Gorde:
| Formatua: | Artikulua |
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| Hizkuntza: | en |
| Argitaratua: |
National Academy of Sciences
2013
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3587232/ https://ncbi.nlm.nih.gov/pubmed/23382200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222863110 |
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