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Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth
Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract and arises from the interstitial cells of Cajal. It is characterized by expression of the receptor tyrosine kinase CD117 (KIT). In 70–80% of GIST cases, oncogenic mutations in KIT are present, leading to c...
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| Médium: | Článek |
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| Jazyk: | en |
| Vydáno: |
National Academy of Sciences
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3587280/ https://ncbi.nlm.nih.gov/pubmed/23382202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222893110 |
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