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Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene
Sphingomyelin synthase (SMS) produces sphingomyelin while consuming ceramide (a negative regulator of cell proliferation) and forming diacylglycerol (DAG) (a mitogenic factor). Therefore, enhanced SMS activity could favor cell proliferation. To examine if dysregulated SMS contributes to leukemogenes...
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| Lenguaje: | en |
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The American Society for Biochemistry and Molecular Biology
2013
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3617953/ https://ncbi.nlm.nih.gov/pubmed/23160178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M033985 |
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