Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.

A new murine homeo-box, called Hox-1.7, has been identified in a rare cDNA from F9 teratocarcinoma stem cells. The Hox-1.7 homeo-box is 68 and 72% homologous to the Drosophila antennapedia (Antp) and iab-7 homeo-boxes, respectively. A major 2.5-kilobase transcript and several minor transcripts were...

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Main Authors: Rubin, M R, King, W, Toth, L E, Sawczuk, I S, Levine, M S, D'Eustachio, P, Nguyen-Huu, M C
Formato: Artigo
Idioma:en
Publicado em: 1987
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC368043/
https://ncbi.nlm.nih.gov/pubmed/2891029
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spelling pubmed-3680432004-03-19 Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression. Rubin, M R King, W Toth, L E Sawczuk, I S Levine, M S D'Eustachio, P Nguyen-Huu, M C Mol Cell Biol Research Article A new murine homeo-box, called Hox-1.7, has been identified in a rare cDNA from F9 teratocarcinoma stem cells. The Hox-1.7 homeo-box is 68 and 72% homologous to the Drosophila antennapedia (Antp) and iab-7 homeo-boxes, respectively. A major 2.5-kilobase transcript and several minor transcripts were detected by Northern blot (RNA blot) analysis in adult tissues as well as in midgestational embryos. The posterior spinal cord was found to be a major site of Hox-1.7 expression in 12.5-day-old embryos. Somatic cell hybrids were used to map the Hox-1.7 gene to mouse chromosome 6. Restriction fragment length polymorphisms associated with either the Hox-1.7 gene or the previously known Hox-1 complex were identified. Their distribution patterns in recombinant inbred mouse strains were used to determine the linkage between the two loci as well as to other loci on chromosome 6. This maps Hox-1 and Hox-1.7 close to two mouse loci that affect morphogenesis, postaxial hemimelia (px) and hypodactyly (Hd). 1987-10 /pmc/articles/PMC368043/ /pubmed/2891029 Text en
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Research Article
spellingShingle Research Article
Rubin, M R
King, W
Toth, L E
Sawczuk, I S
Levine, M S
D'Eustachio, P
Nguyen-Huu, M C
Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.
description A new murine homeo-box, called Hox-1.7, has been identified in a rare cDNA from F9 teratocarcinoma stem cells. The Hox-1.7 homeo-box is 68 and 72% homologous to the Drosophila antennapedia (Antp) and iab-7 homeo-boxes, respectively. A major 2.5-kilobase transcript and several minor transcripts were detected by Northern blot (RNA blot) analysis in adult tissues as well as in midgestational embryos. The posterior spinal cord was found to be a major site of Hox-1.7 expression in 12.5-day-old embryos. Somatic cell hybrids were used to map the Hox-1.7 gene to mouse chromosome 6. Restriction fragment length polymorphisms associated with either the Hox-1.7 gene or the previously known Hox-1 complex were identified. Their distribution patterns in recombinant inbred mouse strains were used to determine the linkage between the two loci as well as to other loci on chromosome 6. This maps Hox-1 and Hox-1.7 close to two mouse loci that affect morphogenesis, postaxial hemimelia (px) and hypodactyly (Hd).
author Rubin, M R
King, W
Toth, L E
Sawczuk, I S
Levine, M S
D'Eustachio, P
Nguyen-Huu, M C
author_facet Rubin, M R
King, W
Toth, L E
Sawczuk, I S
Levine, M S
D'Eustachio, P
Nguyen-Huu, M C
author_sort Rubin, M R
title Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.
title_short Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.
title_full Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.
title_fullStr Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.
title_full_unstemmed Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.
title_sort murine hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.
publishDate 1987
url https://ncbi.nlm.nih.gov/pmc/articles/PMC368043/
https://ncbi.nlm.nih.gov/pubmed/2891029
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