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Human Origin Recognition Complex Binds Preferentially to G-quadruplex-preferable RNA and Single-stranded DNA

Origin recognition complex (ORC), consisting of six subunits ORC1–6, is known to bind to replication origins and function in the initiation of DNA replication in eukaryotic cells. In contrast to the fact that Saccharomyces cerevisiae ORC recognizes the replication origin in a sequence-specific manne...

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Format: Artigo
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Udgivet: American Society for Biochemistry and Molecular Biology 2013
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798484/
https://ncbi.nlm.nih.gov/pubmed/24003239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.492504
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