Genomic environment of variant surface antigen genes of Trypanosoma equiperdum.

Expression of variant antigen genes in Trypanosoma equiperdum is accompanied by the duplication of a silent basic copy gene and the transposition of the copy to an expression site elsewhere in the genome. We have analyzed the genomic locations of both the basic and expression-linked copies of the T....

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Main Authors: Raibaud, A, Gaillard, C, Longacre, S, Hibner, U, Buck, G, Bernardi, G, Eisen, H
格式: Artigo
語言:en
出版: 1983
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC384026/
https://ncbi.nlm.nih.gov/pubmed/6308614
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spelling pubmed-3840262004-04-23 Genomic environment of variant surface antigen genes of Trypanosoma equiperdum. Raibaud, A Gaillard, C Longacre, S Hibner, U Buck, G Bernardi, G Eisen, H Proc Natl Acad Sci U S A Research Article Expression of variant antigen genes in Trypanosoma equiperdum is accompanied by the duplication of a silent basic copy gene and the transposition of the copy to an expression site elsewhere in the genome. We have analyzed the genomic locations of both the basic and expression-linked copies of the T. equiperdum gene for variable surface glycoprotein VSG-1. Both copies are situated proximal to termini in both extracted DNA and in chromatin. The regions between the VSG-1 genes and the termini have a very high buoyant density in CsCl and contain an unidentified nucleoside that replaces deoxycytidine. 1983-07 /pmc/articles/PMC384026/ /pubmed/6308614 Text en
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Research Article
spellingShingle Research Article
Raibaud, A
Gaillard, C
Longacre, S
Hibner, U
Buck, G
Bernardi, G
Eisen, H
Genomic environment of variant surface antigen genes of Trypanosoma equiperdum.
description Expression of variant antigen genes in Trypanosoma equiperdum is accompanied by the duplication of a silent basic copy gene and the transposition of the copy to an expression site elsewhere in the genome. We have analyzed the genomic locations of both the basic and expression-linked copies of the T. equiperdum gene for variable surface glycoprotein VSG-1. Both copies are situated proximal to termini in both extracted DNA and in chromatin. The regions between the VSG-1 genes and the termini have a very high buoyant density in CsCl and contain an unidentified nucleoside that replaces deoxycytidine.
author Raibaud, A
Gaillard, C
Longacre, S
Hibner, U
Buck, G
Bernardi, G
Eisen, H
author_facet Raibaud, A
Gaillard, C
Longacre, S
Hibner, U
Buck, G
Bernardi, G
Eisen, H
author_sort Raibaud, A
title Genomic environment of variant surface antigen genes of Trypanosoma equiperdum.
title_short Genomic environment of variant surface antigen genes of Trypanosoma equiperdum.
title_full Genomic environment of variant surface antigen genes of Trypanosoma equiperdum.
title_fullStr Genomic environment of variant surface antigen genes of Trypanosoma equiperdum.
title_full_unstemmed Genomic environment of variant surface antigen genes of Trypanosoma equiperdum.
title_sort genomic environment of variant surface antigen genes of trypanosoma equiperdum.
publishDate 1983
url https://ncbi.nlm.nih.gov/pmc/articles/PMC384026/
https://ncbi.nlm.nih.gov/pubmed/6308614
_version_ 1759803270875840512

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