Compartmentalization of Spermine and Spermidine in the Herpes Simplex Virion

Enveloped particles of herpes simplex virus produced in human cells in culture contained spermidine and spermine, in a molar ratio of 1.6 ± 0.2. The spermine present within the nucleocapsid is sufficient to neutralize at least 40% of the viral DNA. Disruption of the envelope with nonionic detergent...

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Main Authors: Gibson, Wade, Roizman, Bernard
Formato: Artigo
Idioma:en
Publicado em: 1971
Assuntos:
Biological Sciences: Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC389533/
https://ncbi.nlm.nih.gov/pubmed/5288261
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spelling pubmed-3895332004-04-23 Compartmentalization of Spermine and Spermidine in the Herpes Simplex Virion Gibson, Wade Roizman, Bernard Proc Natl Acad Sci U S A Biological Sciences: Biochemistry Enveloped particles of herpes simplex virus produced in human cells in culture contained spermidine and spermine, in a molar ratio of 1.6 ± 0.2. The spermine present within the nucleocapsid is sufficient to neutralize at least 40% of the viral DNA. Disruption of the envelope with nonionic detergent and urea resulted in the selective loss of spermidine. Exogenous ornithine can function as a precursor to host and viral polyamines only before infection. 1971-11 /pmc/articles/PMC389533/ /pubmed/5288261 Text en
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Biological Sciences: Biochemistry
spellingShingle Biological Sciences: Biochemistry
Gibson, Wade
Roizman, Bernard
Compartmentalization of Spermine and Spermidine in the Herpes Simplex Virion
description Enveloped particles of herpes simplex virus produced in human cells in culture contained spermidine and spermine, in a molar ratio of 1.6 ± 0.2. The spermine present within the nucleocapsid is sufficient to neutralize at least 40% of the viral DNA. Disruption of the envelope with nonionic detergent and urea resulted in the selective loss of spermidine. Exogenous ornithine can function as a precursor to host and viral polyamines only before infection.
author Gibson, Wade
Roizman, Bernard
author_facet Gibson, Wade
Roizman, Bernard
author_sort Gibson, Wade
title Compartmentalization of Spermine and Spermidine in the Herpes Simplex Virion
title_short Compartmentalization of Spermine and Spermidine in the Herpes Simplex Virion
title_full Compartmentalization of Spermine and Spermidine in the Herpes Simplex Virion
title_fullStr Compartmentalization of Spermine and Spermidine in the Herpes Simplex Virion
title_full_unstemmed Compartmentalization of Spermine and Spermidine in the Herpes Simplex Virion
title_sort compartmentalization of spermine and spermidine in the herpes simplex virion
publishDate 1971
url https://ncbi.nlm.nih.gov/pmc/articles/PMC389533/
https://ncbi.nlm.nih.gov/pubmed/5288261
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