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Regulation of HER2 Oncogene Transcription by a Multifunctional Coactivator/Corepressor Complex
Transcription of the HER2 oncogene can be repressed by estrogen (E2). We now show that, a splice isoform of the nuclear receptor coactivator AIB1, AIB1-Δ4, is able to reverse E2 repression of HER2 gene expression in breast cancer cells. The first 224 amino acids of AIB1 that are absent in AIB1-Δ4, b...
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| Lingua: | en |
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Endocrine Society
2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4042073/ https://ncbi.nlm.nih.gov/pubmed/24678732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1379 |
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