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USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling
Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and targeting ALK3 for ubiquitin-mediated degradation...
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| Format: | Artigo |
|---|---|
| Sprog: | en |
| Udgivet: |
The Royal Society
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4042855/ https://ncbi.nlm.nih.gov/pubmed/24850914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.140065 |
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