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Induction of fetal hemoglobin through enhanced translation efficiency of γ-globin mRNA
Fetal hemoglobin (HbF) induction can ameliorate the clinical severity of sickle cell disease and β-thalassemia. We previously reported that activation of the eukaryotic initiation factor 2α (eIF2α) stress pathway increased HbF through a posttranscriptional mechanism. In this study, we explored the u...
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| Format: | Artigo |
|---|---|
| Sprog: | en |
| Udgivet: |
American Society of Hematology
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4208286/ https://ncbi.nlm.nih.gov/pubmed/25170120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-564302 |
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