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Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration.
The missense mutation Lys-296-->Glu (K296E) in the rhodopsin gene produces an opsin with no chromophore binding site and therefore is not activated by light. Nevertheless, the mutant opsin constitutively activates transducin in vitro and causes photoreceptor degeneration in vivo, possibly by cont...
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| Main Authors: | , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | en |
| 出版: |
1995
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC42205/ https://ncbi.nlm.nih.gov/pubmed/7724596 |
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