ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

Examination of the structural basis for antiviral activity, oral pharmacokinetics, and hepatic metabolism among a series of symmetry-based inhibitors of the human immunodeficiency virus (HIV) protease led to the discovery of ABT-538, a promising experimental drug for the therapeutic intervention in...

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Autors principals: Kempf, D J, Marsh, K C, Denissen, J F, McDonald, E, Vasavanonda, S, Flentge, C A, Green, B E, Fino, L, Park, C H, Kong, X P
Format: Article
Idioma:en
Publicat: 1995
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC42242/
https://ncbi.nlm.nih.gov/pubmed/7708670
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https://ncbi.nlm.nih.gov/pmc/articles/PMC42242/
https://ncbi.nlm.nih.gov/pubmed/7708670

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