Membrane Microfilaments of Erythrocytes: Alteration in Intact Cells Reproduces the Hereditary Spherocytosis Syndrome

Membrane microfilaments are found throughout the animal world in situations suggesting that they fulfill a critical role in providing normal cell shape and plasticity. We have hypothesized that hereditary spherocytosis, a congenital hemolytic anemia associated with intrinsically rigid and mishapen e...

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Main Authors: Jacob, Harry, Amsden, Thomas, White, James
Formato: Artigo
Idioma:en
Publicado em: 1972
Assuntos:
Biological Sciences: Medical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC426483/
https://ncbi.nlm.nih.gov/pubmed/4501127
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spelling pubmed-4264832004-07-30 Membrane Microfilaments of Erythrocytes: Alteration in Intact Cells Reproduces the Hereditary Spherocytosis Syndrome Jacob, Harry Amsden, Thomas White, James Proc Natl Acad Sci U S A Biological Sciences: Medical Sciences Membrane microfilaments are found throughout the animal world in situations suggesting that they fulfill a critical role in providing normal cell shape and plasticity. We have hypothesized that hereditary spherocytosis, a congenital hemolytic anemia associated with intrinsically rigid and mishapen erythrocytes, might result from genetically defective microfilaments in erythrocyte membranes. By using three different drugs (vinblastine, colchicine, and strychnine) that share one common attribute—that of potently precipitating purified microfilamentous protein—we have provided support for this hypothesis. Thus, all the known in vitro and in vivo characteristics of hereditary spherocytes are reproduced in normal erythrocytes briefly exposed to these precipitating agents. 1972-02 /pmc/articles/PMC426483/ /pubmed/4501127 Text en
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Biological Sciences: Medical Sciences
spellingShingle Biological Sciences: Medical Sciences
Jacob, Harry
Amsden, Thomas
White, James
Membrane Microfilaments of Erythrocytes: Alteration in Intact Cells Reproduces the Hereditary Spherocytosis Syndrome
description Membrane microfilaments are found throughout the animal world in situations suggesting that they fulfill a critical role in providing normal cell shape and plasticity. We have hypothesized that hereditary spherocytosis, a congenital hemolytic anemia associated with intrinsically rigid and mishapen erythrocytes, might result from genetically defective microfilaments in erythrocyte membranes. By using three different drugs (vinblastine, colchicine, and strychnine) that share one common attribute—that of potently precipitating purified microfilamentous protein—we have provided support for this hypothesis. Thus, all the known in vitro and in vivo characteristics of hereditary spherocytes are reproduced in normal erythrocytes briefly exposed to these precipitating agents.
author Jacob, Harry
Amsden, Thomas
White, James
author_facet Jacob, Harry
Amsden, Thomas
White, James
author_sort Jacob, Harry
title Membrane Microfilaments of Erythrocytes: Alteration in Intact Cells Reproduces the Hereditary Spherocytosis Syndrome
title_short Membrane Microfilaments of Erythrocytes: Alteration in Intact Cells Reproduces the Hereditary Spherocytosis Syndrome
title_full Membrane Microfilaments of Erythrocytes: Alteration in Intact Cells Reproduces the Hereditary Spherocytosis Syndrome
title_fullStr Membrane Microfilaments of Erythrocytes: Alteration in Intact Cells Reproduces the Hereditary Spherocytosis Syndrome
title_full_unstemmed Membrane Microfilaments of Erythrocytes: Alteration in Intact Cells Reproduces the Hereditary Spherocytosis Syndrome
title_sort membrane microfilaments of erythrocytes: alteration in intact cells reproduces the hereditary spherocytosis syndrome
publishDate 1972
url https://ncbi.nlm.nih.gov/pmc/articles/PMC426483/
https://ncbi.nlm.nih.gov/pubmed/4501127
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