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Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases
Viral RNA-dependent RNA polymerases are considered to be low-fidelity enzymes, providing high mutation rates that allow for the rapid adaptation of RNA viruses to different host cell environments. Fidelity is tuned to provide the proper balance of virus replication rates, pathogenesis, and tissue tr...
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| Format: | Članak |
|---|---|
| Jezik: | en |
| Izdano: |
American Society for Microbiology
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4301111/ https://ncbi.nlm.nih.gov/pubmed/25320316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01574-14 |
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