1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

Insulin stimulation drives the formation of a complex between tyrosine-phosphorylated insulin receptor substrate 1 (IRS-1) and 1-phosphatidylinositol 3-kinase (PI 3-kinase; ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase, EC 2.7.1.137), a heterodimer consisting of regulatory 85-kDa (p85) and...

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Autors principals: Hara, K, Yonezawa, K, Sakaue, H, Ando, A, Kotani, K, Kitamura, T, Kitamura, Y, Ueda, H, Stephens, L, Jackson, T R
Format: Article
Idioma:en
Publicat: 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC44411/
https://ncbi.nlm.nih.gov/pubmed/8052599
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https://ncbi.nlm.nih.gov/pmc/articles/PMC44411/
https://ncbi.nlm.nih.gov/pubmed/8052599

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