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Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans
Single-copy transgenes in Caenorhabditis elegans can be subjected to a potent, irreversible silencing process termed small RNA-induced epigenetic silencing (RNAe). RNAe is promoted by the Piwi Argonaute protein PRG-1 and associated Piwi-interacting RNAs (piRNAs), as well as by proteins that promote...
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| Format: | Article |
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| Langue: | en |
| Publié: |
National Academy of Sciences
2015
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4443339/ https://ncbi.nlm.nih.gov/pubmed/25941370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501979112 |
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