Relationship between T-lymphocyte Subsets and Suppressor Cell Activity in Patients with Chronic Active Hepatitis B

Thirty-nine patients with chronic HBV infection and 38 normal persons were investigated by simultaneous assay of T suppressor cell function and enumeration of T-lymphocyte subsets by monoclonal antibodies. In patients with chronic active hepatitis B (CAH-B), T suppressor cell activity (17.8±8.8%) wa...

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Cyhoeddwyd: Korean Association of Internal Medicine 1989
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534976/
https://ncbi.nlm.nih.gov/pubmed/2535041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3904/kjim.1989.4.1.41
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id pubmed-4534976
record_format dspace
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Original Article
spellingShingle Original Article
Relationship between T-lymphocyte Subsets and Suppressor Cell Activity in Patients with Chronic Active Hepatitis B
topic_facet Original Article
description Thirty-nine patients with chronic HBV infection and 38 normal persons were investigated by simultaneous assay of T suppressor cell function and enumeration of T-lymphocyte subsets by monoclonal antibodies. In patients with chronic active hepatitis B (CAH-B), T suppressor cell activity (17.8±8.8%) was significantly lower than in healthy HBsAg carriers (35.4 ± 12.3%) and normal control persons (38.3±16.3%). The proportions of T-lymphocyte subsets in patients with CAH-B were not different from those of healthy HBsAg carriers and control persons. No correlation was observed in between percentage suppression and proportions of T-lymphocyte subsets. These findings suggest that in the absence of a simultaneous assay of function, enumeration of T-lymphocyte subsets by using monoclonal antibodies is an inadequate assessment of immune regulation.
author_sort Jang, Tae Won
title Relationship between T-lymphocyte Subsets and Suppressor Cell Activity in Patients with Chronic Active Hepatitis B
title_short Relationship between T-lymphocyte Subsets and Suppressor Cell Activity in Patients with Chronic Active Hepatitis B
title_full Relationship between T-lymphocyte Subsets and Suppressor Cell Activity in Patients with Chronic Active Hepatitis B
title_fullStr Relationship between T-lymphocyte Subsets and Suppressor Cell Activity in Patients with Chronic Active Hepatitis B
title_full_unstemmed Relationship between T-lymphocyte Subsets and Suppressor Cell Activity in Patients with Chronic Active Hepatitis B
title_sort relationship between t-lymphocyte subsets and suppressor cell activity in patients with chronic active hepatitis b
publisher Korean Association of Internal Medicine
publisher_facet Korean Association of Internal Medicine
publishDate 1989
url https://ncbi.nlm.nih.gov/pmc/articles/PMC4534976/
https://ncbi.nlm.nih.gov/pubmed/2535041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3904/kjim.1989.4.1.41
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