Long-term retention of learning-induced receptive-field plasticity in the auditory cortex.

Brief learning experience (classical conditioning) induces frequency-specific receptive-field (RF) plasticity in the auditory cortex, characterized as increased response to the frequency of the conditioned stimulus and decreased responses to most other frequencies, including the pretraining best fre...

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Main Authors: Weinberger, N M, Javid, R, Lepan, B
Formato: Artigo
Idioma:en
Publicado em: 1993
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC46093/
https://ncbi.nlm.nih.gov/pubmed/8460150
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spelling pubmed-460932001-08-25 Long-term retention of learning-induced receptive-field plasticity in the auditory cortex. Weinberger, N M Javid, R Lepan, B Proc Natl Acad Sci U S A Research Article Brief learning experience (classical conditioning) induces frequency-specific receptive-field (RF) plasticity in the auditory cortex, characterized as increased response to the frequency of the conditioned stimulus and decreased responses to most other frequencies, including the pretraining best frequency. This experiment asked (i) whether learning-induced RF plasticity, established in the waking state, can be expressed under general anesthesia and if so (ii) whether it exhibits long-term retention. Pure-tone-frequency RFs were obtained from adult guinea pigs under general anesthesia (sodium pentobarbital or ketamine) before and repeatedly after (1 hr-8 weeks) a 20- to 30-trial session of pairing a non-best-frequency tone with mild footshock. Conditioned-stimulus-specific RF plasticity was expressed under both types of anesthesia and included shifts of the pretraining best frequency toward or even to the frequency of the conditioned stimulus. Moreover, this RF plasticity exhibits long-term retention, being evident 1-8 weeks after training. This satisfies a criterion for the long-term storage of information in the auditory cortex. 1993-03-15 /pmc/articles/PMC46093/ /pubmed/8460150 Text en
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Research Article
spellingShingle Research Article
Weinberger, N M
Javid, R
Lepan, B
Long-term retention of learning-induced receptive-field plasticity in the auditory cortex.
description Brief learning experience (classical conditioning) induces frequency-specific receptive-field (RF) plasticity in the auditory cortex, characterized as increased response to the frequency of the conditioned stimulus and decreased responses to most other frequencies, including the pretraining best frequency. This experiment asked (i) whether learning-induced RF plasticity, established in the waking state, can be expressed under general anesthesia and if so (ii) whether it exhibits long-term retention. Pure-tone-frequency RFs were obtained from adult guinea pigs under general anesthesia (sodium pentobarbital or ketamine) before and repeatedly after (1 hr-8 weeks) a 20- to 30-trial session of pairing a non-best-frequency tone with mild footshock. Conditioned-stimulus-specific RF plasticity was expressed under both types of anesthesia and included shifts of the pretraining best frequency toward or even to the frequency of the conditioned stimulus. Moreover, this RF plasticity exhibits long-term retention, being evident 1-8 weeks after training. This satisfies a criterion for the long-term storage of information in the auditory cortex.
author Weinberger, N M
Javid, R
Lepan, B
author_facet Weinberger, N M
Javid, R
Lepan, B
author_sort Weinberger, N M
title Long-term retention of learning-induced receptive-field plasticity in the auditory cortex.
title_short Long-term retention of learning-induced receptive-field plasticity in the auditory cortex.
title_full Long-term retention of learning-induced receptive-field plasticity in the auditory cortex.
title_fullStr Long-term retention of learning-induced receptive-field plasticity in the auditory cortex.
title_full_unstemmed Long-term retention of learning-induced receptive-field plasticity in the auditory cortex.
title_sort long-term retention of learning-induced receptive-field plasticity in the auditory cortex.
publishDate 1993
url https://ncbi.nlm.nih.gov/pmc/articles/PMC46093/
https://ncbi.nlm.nih.gov/pubmed/8460150
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