Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system.

We report experiments in the rat demonstrating the feasibility of intraventricular administration of oligodeoxynucleotides (ODNs) as a regional treatment approach to disorders within the central nervous system (CNS). Although we find little intrinsic nuclease activity in cerebrospinal fluid (CSF), p...

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Detaylı Bibliyografya
Asıl Yazarlar: Whitesell, L, Geselowitz, D, Chavany, C, Fahmy, B, Walbridge, S, Alger, J R, Neckers, L M
Materyal Türü: Makale
Dil:en
Baskı/Yayın Bilgisi: 1993
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC46573/
https://ncbi.nlm.nih.gov/pubmed/8506315
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC46573/
https://ncbi.nlm.nih.gov/pubmed/8506315

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