Murine Model of Pulmonary Anthrax: Kinetics of Dissemination, Histopathology, and Mouse Strain Susceptibility

Bioweapons are most often designed for delivery to the lung, although this route is not the usual portal of entry for many of the pathogens in the natural environment. Vaccines and therapeutics that are efficacious for natural routes of infection may not be effective against the pulmonary route. Pul...

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Main Authors: Lyons, C. Rick, Lovchik, Julie, Hutt, Julie, Lipscomb, Mary F., Wang, Eugenia, Heninger, Sara, Berliba, Lucy, Garrison, Kristin
Formato: Artigo
Idioma:English
Publicado em: American Society for Microbiology 2004
Assuntos:
Bacterial Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC470666/
https://ncbi.nlm.nih.gov/pubmed/15271942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.8.4801-4809.2004
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spelling pubmed-4706662004-09-30 Murine Model of Pulmonary Anthrax: Kinetics of Dissemination, Histopathology, and Mouse Strain Susceptibility Lyons, C. Rick Lovchik, Julie Hutt, Julie Lipscomb, Mary F. Wang, Eugenia Heninger, Sara Berliba, Lucy Garrison, Kristin Infect Immun Bacterial Infections Bioweapons are most often designed for delivery to the lung, although this route is not the usual portal of entry for many of the pathogens in the natural environment. Vaccines and therapeutics that are efficacious for natural routes of infection may not be effective against the pulmonary route. Pulmonary models are needed to investigate the importance of specific bacterial genes in virulence, to identify components of the host immune system that are important in providing innate and acquired protection, and for testing diagnostic and therapeutic strategies. This report describes the characteristics of host and Bacillus anthracis interactions in a murine pulmonary-infection model. The infective dose varied depending on the route and method of inoculation. The germination process in the lung began within 1 h of inoculation into the lung, although growth within the lung was limited. B. anthracis was found in the lung-associated lymph nodes ∼5 h after infection. Minimal pneumonitis was associated with the lung infection, but significant systemic pathology was noted after dissemination. Infected mice typically succumbed to infection ∼3 to 4 days after inoculation. The 50% lethal doses differed among inbred strains of mice, but within a given mouse strain, neither the age nor the sex of the mice influenced susceptibility to B. anthracis. American Society for Microbiology 2004-08 /pmc/articles/PMC470666/ /pubmed/15271942 http://dx.doi.org/10.1128/IAI.72.8.4801-4809.2004 Text en Copyright © 2004, American Society for Microbiology
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Bacterial Infections
spellingShingle Bacterial Infections
Lyons, C. Rick
Lovchik, Julie
Hutt, Julie
Lipscomb, Mary F.
Wang, Eugenia
Heninger, Sara
Berliba, Lucy
Garrison, Kristin
Murine Model of Pulmonary Anthrax: Kinetics of Dissemination, Histopathology, and Mouse Strain Susceptibility
description Bioweapons are most often designed for delivery to the lung, although this route is not the usual portal of entry for many of the pathogens in the natural environment. Vaccines and therapeutics that are efficacious for natural routes of infection may not be effective against the pulmonary route. Pulmonary models are needed to investigate the importance of specific bacterial genes in virulence, to identify components of the host immune system that are important in providing innate and acquired protection, and for testing diagnostic and therapeutic strategies. This report describes the characteristics of host and Bacillus anthracis interactions in a murine pulmonary-infection model. The infective dose varied depending on the route and method of inoculation. The germination process in the lung began within 1 h of inoculation into the lung, although growth within the lung was limited. B. anthracis was found in the lung-associated lymph nodes ∼5 h after infection. Minimal pneumonitis was associated with the lung infection, but significant systemic pathology was noted after dissemination. Infected mice typically succumbed to infection ∼3 to 4 days after inoculation. The 50% lethal doses differed among inbred strains of mice, but within a given mouse strain, neither the age nor the sex of the mice influenced susceptibility to B. anthracis.
author Lyons, C. Rick
Lovchik, Julie
Hutt, Julie
Lipscomb, Mary F.
Wang, Eugenia
Heninger, Sara
Berliba, Lucy
Garrison, Kristin
author_facet Lyons, C. Rick
Lovchik, Julie
Hutt, Julie
Lipscomb, Mary F.
Wang, Eugenia
Heninger, Sara
Berliba, Lucy
Garrison, Kristin
author_sort Lyons, C. Rick
title Murine Model of Pulmonary Anthrax: Kinetics of Dissemination, Histopathology, and Mouse Strain Susceptibility
title_short Murine Model of Pulmonary Anthrax: Kinetics of Dissemination, Histopathology, and Mouse Strain Susceptibility
title_full Murine Model of Pulmonary Anthrax: Kinetics of Dissemination, Histopathology, and Mouse Strain Susceptibility
title_fullStr Murine Model of Pulmonary Anthrax: Kinetics of Dissemination, Histopathology, and Mouse Strain Susceptibility
title_full_unstemmed Murine Model of Pulmonary Anthrax: Kinetics of Dissemination, Histopathology, and Mouse Strain Susceptibility
title_sort murine model of pulmonary anthrax: kinetics of dissemination, histopathology, and mouse strain susceptibility
publisher American Society for Microbiology
publisher_facet American Society for Microbiology
publishDate 2004
url https://ncbi.nlm.nih.gov/pmc/articles/PMC470666/
https://ncbi.nlm.nih.gov/pubmed/15271942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.8.4801-4809.2004
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