Vitamin B(12) absorption studies: effect of parenteral non-radioactive vitamin B(12) on serum level of (57)Co vitamin B(12)

The intestinal absorption of (57)Co vitamin B(12) has been measured by counting the radioactivity in the serum, and the effect of the parenteral administration of 1 mg. non-radioactive vitamin B(12) two hours after the oral dose has been studied. When parenteral vitamin B(12) was not given, the mean...

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Main Authors: Harwood, Lilian, Forshaw, J.
Formato: Artigo
Idioma:English
Publicado em: 1967
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC473551/
https://ncbi.nlm.nih.gov/pubmed/5602975
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spelling pubmed-4735512005-10-03 Vitamin B(12) absorption studies: effect of parenteral non-radioactive vitamin B(12) on serum level of (57)Co vitamin B(12) Harwood, Lilian Forshaw, J. J Clin Pathol Articles The intestinal absorption of (57)Co vitamin B(12) has been measured by counting the radioactivity in the serum, and the effect of the parenteral administration of 1 mg. non-radioactive vitamin B(12) two hours after the oral dose has been studied. When parenteral vitamin B(12) was not given, the mean radioactivity in the serum was lower in both patients with pernicious anaemia and in control subjects, and the results in the patients with pernicious anaemia were more definitive. There was no significant difference between the results obtained with an Ekco scaler and those with an I.D.L. scaler. This is the simplest and most convenient method of measuring vitamin B(12) absorption. It is suggested that the test be standardized by giving 0·5 μg. (57)Co vitamin B(12) with a maximal histamine stimulation of intrinsic factor secretion, but without a parenteral dose of non-radioactive vitamin B(12). The results are expressed most usefully as a percentage of the administered dose per litre of serum or plasma. 1967-09 /pmc/articles/PMC473551/ /pubmed/5602975 Text en
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Articles
spellingShingle Articles
Harwood, Lilian
Forshaw, J.
Vitamin B(12) absorption studies: effect of parenteral non-radioactive vitamin B(12) on serum level of (57)Co vitamin B(12)
description The intestinal absorption of (57)Co vitamin B(12) has been measured by counting the radioactivity in the serum, and the effect of the parenteral administration of 1 mg. non-radioactive vitamin B(12) two hours after the oral dose has been studied. When parenteral vitamin B(12) was not given, the mean radioactivity in the serum was lower in both patients with pernicious anaemia and in control subjects, and the results in the patients with pernicious anaemia were more definitive. There was no significant difference between the results obtained with an Ekco scaler and those with an I.D.L. scaler. This is the simplest and most convenient method of measuring vitamin B(12) absorption. It is suggested that the test be standardized by giving 0·5 μg. (57)Co vitamin B(12) with a maximal histamine stimulation of intrinsic factor secretion, but without a parenteral dose of non-radioactive vitamin B(12). The results are expressed most usefully as a percentage of the administered dose per litre of serum or plasma.
author Harwood, Lilian
Forshaw, J.
author_facet Harwood, Lilian
Forshaw, J.
author_sort Harwood, Lilian
title Vitamin B(12) absorption studies: effect of parenteral non-radioactive vitamin B(12) on serum level of (57)Co vitamin B(12)
title_short Vitamin B(12) absorption studies: effect of parenteral non-radioactive vitamin B(12) on serum level of (57)Co vitamin B(12)
title_full Vitamin B(12) absorption studies: effect of parenteral non-radioactive vitamin B(12) on serum level of (57)Co vitamin B(12)
title_fullStr Vitamin B(12) absorption studies: effect of parenteral non-radioactive vitamin B(12) on serum level of (57)Co vitamin B(12)
title_full_unstemmed Vitamin B(12) absorption studies: effect of parenteral non-radioactive vitamin B(12) on serum level of (57)Co vitamin B(12)
title_sort vitamin b(12) absorption studies: effect of parenteral non-radioactive vitamin b(12) on serum level of (57)co vitamin b(12)
publishDate 1967
url https://ncbi.nlm.nih.gov/pmc/articles/PMC473551/
https://ncbi.nlm.nih.gov/pubmed/5602975
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