Haemodynamic effects of acute beta-adrenergic receptor blockade in congestive cardiomyopathy.

Acebutolol ('Sectral'), a cardioselective beta-blocking drug, was administered intravenously in a dose of 25 mg to 10 patients with congestive cardiomyopathy. All of them were in a stable condition on antifailure regimens. The drug resulted in a statistically significant decline in left ve...

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Main Authors: Ikram, H, Chan, W, Bennett, S I, Bones, P J
Formato: Artigo
Idioma:English
Publicado em: 1979
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC482153/
https://ncbi.nlm.nih.gov/pubmed/508453
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spelling pubmed-4821532007-06-20 Haemodynamic effects of acute beta-adrenergic receptor blockade in congestive cardiomyopathy. Ikram, H Chan, W Bennett, S I Bones, P J Br Heart J Research Article Acebutolol ('Sectral'), a cardioselective beta-blocking drug, was administered intravenously in a dose of 25 mg to 10 patients with congestive cardiomyopathy. All of them were in a stable condition on antifailure regimens. The drug resulted in a statistically significant decline in left ventricular contractility as judged by peak left ventricular dP/dT and the contractility index. The mean aortic blood pressure also fell. There was a significant increase in end-diastolic and end-systolic left ventricular volumes. Mean values for heart rate, ejection fraction, left ventricular stroke work index, and cardiac output also fell, but the results were not statistically significant. Left ventricular distensibility as judged by the slope of the diastolic pressure-volume relation also improved significantly. A reduction in myocardial energy requirements, improved compliance, and lowering of arterial pressure would be haemodynamically advantageous. However, further cardiac dilatation and reduction contractility--the basic defects in congestive cardiomyopathy--could lead to further deterioration. 1979-09 /pmc/articles/PMC482153/ /pubmed/508453 Text en
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Research Article
spellingShingle Research Article
Ikram, H
Chan, W
Bennett, S I
Bones, P J
Haemodynamic effects of acute beta-adrenergic receptor blockade in congestive cardiomyopathy.
description Acebutolol ('Sectral'), a cardioselective beta-blocking drug, was administered intravenously in a dose of 25 mg to 10 patients with congestive cardiomyopathy. All of them were in a stable condition on antifailure regimens. The drug resulted in a statistically significant decline in left ventricular contractility as judged by peak left ventricular dP/dT and the contractility index. The mean aortic blood pressure also fell. There was a significant increase in end-diastolic and end-systolic left ventricular volumes. Mean values for heart rate, ejection fraction, left ventricular stroke work index, and cardiac output also fell, but the results were not statistically significant. Left ventricular distensibility as judged by the slope of the diastolic pressure-volume relation also improved significantly. A reduction in myocardial energy requirements, improved compliance, and lowering of arterial pressure would be haemodynamically advantageous. However, further cardiac dilatation and reduction contractility--the basic defects in congestive cardiomyopathy--could lead to further deterioration.
author Ikram, H
Chan, W
Bennett, S I
Bones, P J
author_facet Ikram, H
Chan, W
Bennett, S I
Bones, P J
author_sort Ikram, H
title Haemodynamic effects of acute beta-adrenergic receptor blockade in congestive cardiomyopathy.
title_short Haemodynamic effects of acute beta-adrenergic receptor blockade in congestive cardiomyopathy.
title_full Haemodynamic effects of acute beta-adrenergic receptor blockade in congestive cardiomyopathy.
title_fullStr Haemodynamic effects of acute beta-adrenergic receptor blockade in congestive cardiomyopathy.
title_full_unstemmed Haemodynamic effects of acute beta-adrenergic receptor blockade in congestive cardiomyopathy.
title_sort haemodynamic effects of acute beta-adrenergic receptor blockade in congestive cardiomyopathy.
publishDate 1979
url https://ncbi.nlm.nih.gov/pmc/articles/PMC482153/
https://ncbi.nlm.nih.gov/pubmed/508453
_version_ 1759823389618339840

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