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Vicinal cysteines in the prosequence play a role in von Willebrand factor multimer assembly.
von Willebrand factor (vWf) is synthesized as a large precursor that dimerizes in the endoplasmic reticulum and forms multimers in the trans- and post-Golgi compartments of megakaryocytes and endothelial cells. The disulfide-bonded multimers are stored in alpha granules of platelets and Weibel-Palad...
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| Auteurs principaux: | , |
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| Format: | Article |
| Langue: | en |
| Publié: |
1992
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC48902/ https://ncbi.nlm.nih.gov/pubmed/1565649 |
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