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Isoform specificity of cardiac glycosides binding to human Na(+),K(+)-ATPase α(1)β(1), α(2)β(1) and α(3)β(1)
Cardiac glycosides inhibit the Na(+),K(+)-ATPase and are used for the treatment of symptomatic heart failure and atrial fibrillation. In human heart three isoforms of Na(+),K(+)-ATPase are expressed: α(1)β(1), α(2)β(1) and α(3)β(1). It is unknown, if clinically used cardiac glycosides differ in isof...
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| Lingua: | en |
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2009
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4948948/ https://ncbi.nlm.nih.gov/pubmed/19751721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2009.08.039 |
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