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Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector.
Gene therapy of severe hemoglobinopathies will require high-level expression of a transferred globin gene in erythroid cells. Distant regulatory elements flanking the beta-globin gene cluster, the locus control region, are needed for appropriate expression. We have explored the use of a human parvov...
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| 主要な著者: | , , , , , |
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| フォーマット: | 論文 |
| 言語: | en |
| 出版事項: |
1992
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC49685/ https://ncbi.nlm.nih.gov/pubmed/1323131 |
| タグ: |
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