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Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector.
Gene therapy of severe hemoglobinopathies will require high-level expression of a transferred globin gene in erythroid cells. Distant regulatory elements flanking the beta-globin gene cluster, the locus control region, are needed for appropriate expression. We have explored the use of a human parvov...
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| Главные авторы: | , , , , , |
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| Формат: | Статья |
| Язык: | en |
| Опубликовано: |
1992
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC49685/ https://ncbi.nlm.nih.gov/pubmed/1323131 |
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