C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia.

Serial monitoring of the serum C-reactive protein (CRP) concentration was performed, using a one-hour laser-immunonephelometric assay, during 29 episodes of infection in 22 neutropenic patients with acute leukaemia. Serum CRP increased to above a diagnostic level of 100 mg/l in all 29 episodes and c...

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Main Authors: Schofield, K P, Voulgari, F, Gozzard, D I, Leyland, M J, Beeching, N J, Stuart, J
Formato: Artigo
Idioma:English
Publicado em: 1982
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC497805/
https://ncbi.nlm.nih.gov/pubmed/7107959
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spelling pubmed-4978052005-10-03 C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia. Schofield, K P Voulgari, F Gozzard, D I Leyland, M J Beeching, N J Stuart, J J Clin Pathol Research Article Serial monitoring of the serum C-reactive protein (CRP) concentration was performed, using a one-hour laser-immunonephelometric assay, during 29 episodes of infection in 22 neutropenic patients with acute leukaemia. Serum CRP increased to above a diagnostic level of 100 mg/l in all 29 episodes and continued to rise progressively until appropriate antibiotics, or granulocytes, were given when it fell with a half-life of approximately three days. Serial study of the serum concentration was of value in detecting occult or unresolved bacterial infection and provided an objective means of monitoring the response to antibiotic and granulocyte therapy. 1982-08 /pmc/articles/PMC497805/ /pubmed/7107959 Text en
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Research Article
spellingShingle Research Article
Schofield, K P
Voulgari, F
Gozzard, D I
Leyland, M J
Beeching, N J
Stuart, J
C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia.
description Serial monitoring of the serum C-reactive protein (CRP) concentration was performed, using a one-hour laser-immunonephelometric assay, during 29 episodes of infection in 22 neutropenic patients with acute leukaemia. Serum CRP increased to above a diagnostic level of 100 mg/l in all 29 episodes and continued to rise progressively until appropriate antibiotics, or granulocytes, were given when it fell with a half-life of approximately three days. Serial study of the serum concentration was of value in detecting occult or unresolved bacterial infection and provided an objective means of monitoring the response to antibiotic and granulocyte therapy.
author Schofield, K P
Voulgari, F
Gozzard, D I
Leyland, M J
Beeching, N J
Stuart, J
author_facet Schofield, K P
Voulgari, F
Gozzard, D I
Leyland, M J
Beeching, N J
Stuart, J
author_sort Schofield, K P
title C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia.
title_short C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia.
title_full C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia.
title_fullStr C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia.
title_full_unstemmed C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia.
title_sort c-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia.
publishDate 1982
url https://ncbi.nlm.nih.gov/pmc/articles/PMC497805/
https://ncbi.nlm.nih.gov/pubmed/7107959
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