Carregant...
The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length
Telomeres are involved in the maintenance of chromosomes and the prevention of genome instability. Despite this central importance, significant variation in telomere length has been observed in a variety of organisms. The genetic determinants of telomere-length variation and their effects on organis...
Guardat en:
| Format: | Article |
|---|---|
| Idioma: | en |
| Publicat: |
Genetics Society of America
2016
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5012401/ https://ncbi.nlm.nih.gov/pubmed/27449056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.191148 |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|
| id |
pubmed-5012401 |
|---|---|
| record_format |
dspace |
| institution |
US National Library of Medicine |
| collection |
PubMed Central |
| language |
en |
| format |
Article |
| topic |
Investigations |
| spellingShingle |
Investigations The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length |
| topic_facet |
Investigations |
| description |
Telomeres are involved in the maintenance of chromosomes and the prevention of genome instability. Despite this central importance, significant variation in telomere length has been observed in a variety of organisms. The genetic determinants of telomere-length variation and their effects on organismal fitness are largely unexplored. Here, we describe natural variation in telomere length across the Caenorhabditis elegans species. We identify a large-effect variant that contributes to differences in telomere length. The variant alters the conserved oligonucleotide/oligosaccharide-binding fold of protection of telomeres 2 (POT-2), a homolog of a human telomere-capping shelterin complex subunit. Mutations within this domain likely reduce the ability of POT-2 to bind telomeric DNA, thereby increasing telomere length. We find that telomere-length variation does not correlate with offspring production or longevity in C. elegans wild isolates, suggesting that naturally long telomeres play a limited role in modifying fitness phenotypes in C. elegans. |
| author_sort |
Cook, Daniel E. |
| title |
The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length |
| title_short |
The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length |
| title_full |
The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length |
| title_fullStr |
The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length |
| title_full_unstemmed |
The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length |
| title_sort |
genetic basis of natural variation in caenorhabditis elegans telomere length |
| publisher |
Genetics Society of America |
| publisher_facet |
Genetics Society of America |
| publishDate |
2016 |
| url |
https://ncbi.nlm.nih.gov/pmc/articles/PMC5012401/ https://ncbi.nlm.nih.gov/pubmed/27449056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.191148 |
| _version_ |
1872506664035287041 |