Cross-Regulation among the Polycomb Group Genes in Drosophila melanogaster

Genes of the Polycomb group in Drosophila melanogaster function as long-term transcriptional repressors. A few members of the group encode proteins found in two evolutionarily conserved chromatin complexes, Polycomb repressive complex 1 (PRC1) and the ESC-E(Z) complex. The majority of the group, lac...

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Main Authors: Ali, Janann Y., Bender, Welcome
Formato: Artigo
Idioma:English
Publicado em: American Society for Microbiology 2004
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC507012/
https://ncbi.nlm.nih.gov/pubmed/15314179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.17.7737-7747.2004
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spelling pubmed-5070122004-09-14 Cross-Regulation among the Polycomb Group Genes in Drosophila melanogaster Ali, Janann Y. Bender, Welcome Mol Cell Biol Transcriptional Regulation Genes of the Polycomb group in Drosophila melanogaster function as long-term transcriptional repressors. A few members of the group encode proteins found in two evolutionarily conserved chromatin complexes, Polycomb repressive complex 1 (PRC1) and the ESC-E(Z) complex. The majority of the group, lacking clear biochemical functions, might be indirect regulators. The transcript levels of seven Polycomb group genes were assayed in embryos mutant for various other genes in the family. Three Polycomb group genes were identified as upstream positive regulators of the core components of PRC1. There is also negative feedback regulation of some PRC1 core components by other PRC1 genes. Finally, there is positive regulation of PRC1 components by the ESC-E(Z) complex. These multiple pathways of cross-regulation help to explain the large size of the Polycomb group family of genes, but they complicate the genetic analysis of any single member. American Society for Microbiology 2004-09 /pmc/articles/PMC507012/ /pubmed/15314179 http://dx.doi.org/10.1128/MCB.24.17.7737-7747.2004 Text en Copyright © 2004, American Society for Microbiology
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Transcriptional Regulation
spellingShingle Transcriptional Regulation
Ali, Janann Y.
Bender, Welcome
Cross-Regulation among the Polycomb Group Genes in Drosophila melanogaster
description Genes of the Polycomb group in Drosophila melanogaster function as long-term transcriptional repressors. A few members of the group encode proteins found in two evolutionarily conserved chromatin complexes, Polycomb repressive complex 1 (PRC1) and the ESC-E(Z) complex. The majority of the group, lacking clear biochemical functions, might be indirect regulators. The transcript levels of seven Polycomb group genes were assayed in embryos mutant for various other genes in the family. Three Polycomb group genes were identified as upstream positive regulators of the core components of PRC1. There is also negative feedback regulation of some PRC1 core components by other PRC1 genes. Finally, there is positive regulation of PRC1 components by the ESC-E(Z) complex. These multiple pathways of cross-regulation help to explain the large size of the Polycomb group family of genes, but they complicate the genetic analysis of any single member.
author Ali, Janann Y.
Bender, Welcome
author_facet Ali, Janann Y.
Bender, Welcome
author_sort Ali, Janann Y.
title Cross-Regulation among the Polycomb Group Genes in Drosophila melanogaster
title_short Cross-Regulation among the Polycomb Group Genes in Drosophila melanogaster
title_full Cross-Regulation among the Polycomb Group Genes in Drosophila melanogaster
title_fullStr Cross-Regulation among the Polycomb Group Genes in Drosophila melanogaster
title_full_unstemmed Cross-Regulation among the Polycomb Group Genes in Drosophila melanogaster
title_sort cross-regulation among the polycomb group genes in drosophila melanogaster
publisher American Society for Microbiology
publisher_facet American Society for Microbiology
publishDate 2004
url https://ncbi.nlm.nih.gov/pmc/articles/PMC507012/
https://ncbi.nlm.nih.gov/pubmed/15314179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.17.7737-7747.2004
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