Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.

To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage, metabolic fragments of aggrecan were detected with monospecific antipeptide antibodies. The distribution and quantity of MMP-generated aggrecan G1 fragments terminating in V...

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Main Authors: Lark, M W, Bayne, E K, Flanagan, J, Harper, C F, Hoerrner, L A, Hutchinson, N I, Singer, I I, Donatelli, S A, Weidner, J R, Williams, H R, Mumford, R A, Lohmander, L S
格式: Artigo
語言:English
出版: 1997
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC508169/
https://ncbi.nlm.nih.gov/pubmed/9202061
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