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Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance.
The development of preclinical models for the rapid testing of agents that circumvent multidrug resistance in cancer is a high priority of research on drug resistance. A common form of multidrug resistance in human cancer results from expression of the MDR1 gene, which encodes a Mr 170,000 glycoprot...
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| 主要な著者: | , , , , |
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| フォーマット: | 論文 |
| 言語: | en |
| 出版事項: |
1991
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC50848/ https://ncbi.nlm.nih.gov/pubmed/1671173 |
| タグ: |
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