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Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex
Proteins are often engineered to have higher affinity for their ligands to achieve therapeutic benefit. For example, many studies have used phage or yeast display libraries of mutants within complementarity-determining regions to affinity mature antibodies and T cell receptors (TCRs). However, these...
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| Format: | Artikel |
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| Sprache: | en |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5114409/ https://ncbi.nlm.nih.gov/pubmed/27681597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748681 |
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