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Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa
[Image: see text] The Gram-negative bacterial pathogen Pseudomonas aeruginosa uses three interconnected intercellular signaling systems regulated by the transcription factors LasR, RhlR, and MvfR (PqsR), which mediate bacterial cell–cell communication via small-molecule natural products and control...
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| Format: | Article |
|---|---|
| Langue: | en |
| Publié: |
American Chemical
Society
2016
|
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5117135/ https://ncbi.nlm.nih.gov/pubmed/27658001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00575 |
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