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Transcription influences the types of deletion and expansion products in an orientation-dependent manner from GAC•GTC repeats
The genetic instability of (GAC•GTC)(n) (where n = 6–74) was investigated in an Escherichia coli-based plasmid system. Prior work implicated the instability of a (GAC•GTC)(5) tract in the cartilage oligomeric matrix protein (COMP) gene to the 4, 6 or 7mers in the etiology of pseudoachondroplasia and...
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| Format: | Artikel |
| Sprache: | English |
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Oxford University Press
2004
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC516059/ https://ncbi.nlm.nih.gov/pubmed/15317871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh787 |
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