A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1

Lv1 restriction of HIV-1 in the cells of Old World monkeys is associated with the expression of the Trim5 gene. Uniquely, in owl monkey kidney cells, HIV-1 restriction is dependent on the ability of incoming viral capsid protein to bind cyclophilin A (CypA). Cloning of the owl monkey Trim5 gene now...

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Main Authors: Nisole, Sébastien, Lynch, Clare, Stoye, Jonathan P., Yap, Melvyn W.
Formato: Artigo
Idioma:English
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC516566/
https://ncbi.nlm.nih.gov/pubmed/15326303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404640101
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spelling pubmed-5165662005-03-07 A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1 Nisole, Sébastien Lynch, Clare Stoye, Jonathan P. Yap, Melvyn W. Proc Natl Acad Sci U S A Biological Sciences Lv1 restriction of HIV-1 in the cells of Old World monkeys is associated with the expression of the Trim5 gene. Uniquely, in owl monkey kidney cells, HIV-1 restriction is dependent on the ability of incoming viral capsid protein to bind cyclophilin A (CypA). Cloning of the owl monkey Trim5 gene now reveals the presence of an inserted CypA pseudogene within intron 7 of the Trim5 gene. This insertion results in the formation of a chimeric Trim5-CypA transcript. Transfer of a cDNA corresponding to this transcript into human cells confers cyclosporin A-sensitive resistance to HIV-1 infection. The restriction factor appears to be a chimeric protein created by retrotransposon-mediated exon shuffling. National Academy of Sciences 2004-09-07 2004-08-23 /pmc/articles/PMC516566/ /pubmed/15326303 http://dx.doi.org/10.1073/pnas.0404640101 Text en Copyright © 2004, The National Academy of Sciences
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Biological Sciences
spellingShingle Biological Sciences
Nisole, Sébastien
Lynch, Clare
Stoye, Jonathan P.
Yap, Melvyn W.
A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1
description Lv1 restriction of HIV-1 in the cells of Old World monkeys is associated with the expression of the Trim5 gene. Uniquely, in owl monkey kidney cells, HIV-1 restriction is dependent on the ability of incoming viral capsid protein to bind cyclophilin A (CypA). Cloning of the owl monkey Trim5 gene now reveals the presence of an inserted CypA pseudogene within intron 7 of the Trim5 gene. This insertion results in the formation of a chimeric Trim5-CypA transcript. Transfer of a cDNA corresponding to this transcript into human cells confers cyclosporin A-sensitive resistance to HIV-1 infection. The restriction factor appears to be a chimeric protein created by retrotransposon-mediated exon shuffling.
author Nisole, Sébastien
Lynch, Clare
Stoye, Jonathan P.
Yap, Melvyn W.
author_facet Nisole, Sébastien
Lynch, Clare
Stoye, Jonathan P.
Yap, Melvyn W.
author_sort Nisole, Sébastien
title A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1
title_short A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1
title_full A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1
title_fullStr A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1
title_full_unstemmed A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1
title_sort trim5-cyclophilin a fusion protein found in owl monkey kidney cells can restrict hiv-1
publisher National Academy of Sciences
publisher_facet National Academy of Sciences
publishDate 2004
url https://ncbi.nlm.nih.gov/pmc/articles/PMC516566/
https://ncbi.nlm.nih.gov/pubmed/15326303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404640101
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