The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins

Presenilins (PSs) are required for Notch signaling in the development of vertebrates and invertebrates. Mutations in human PS1 and PS2 homologs are a cause of familial Alzheimer's disease (AD). The function of the recently identified ancient family of IMPAS proteins (IMP/SPP/PSH) homologous to...

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Bibliografski detalji
Glavni autori: Grigorenko, Anastasia P., Moliaka, Yuri K., Soto, Martha C., Mello, Craig C., Rogaev, Evgeny I.
Format: Članak
Jezik:English
Izdano: National Academy of Sciences 2004
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC522053/
https://ncbi.nlm.nih.gov/pubmed/15469912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406462101
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https://ncbi.nlm.nih.gov/pmc/articles/PMC522053/
https://ncbi.nlm.nih.gov/pubmed/15469912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406462101

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