A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells

Many key regulatory proteins, including members of the Ras family of GTPases, are modified at their C terminus by a process termed prenylation. This processing is initiated by the addition of an isoprenoid lipid, and the proteins are further modified by a proteolytic event and methylation of the C-t...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Winter-Vann, Ann M., Baron, Rudi A., Wong, Waihay, dela Cruz, June, York, John D., Gooden, David M., Bergo, Martin O., Young, Stephen G., Toone, Eric J., Casey, Patrick J.
Μορφή:	Άρθρο
Γλώσσα:	English
Έκδοση:	National Academy of Sciences 2005
Θέματα:	Biological Sciences
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC555472/ https://ncbi.nlm.nih.gov/pubmed/15784746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408107102
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