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Differential DNA recognition and glycosylase activity of the native human MutY homolog (hMYH) and recombinant hMYH expressed in bacteria
Human MutY homolog (hMYH), an adenine DNA glycosylase, can effectively remove misincorporated adenines opposite template G or 8-oxoG bases, thereby preventing G:C→T:A transversions. Human cell extracts possess the adenine DNA glycosylase activity of hMYH and can form protein–DNA complexes with both...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | en |
| Publicado: |
Oxford University Press
2001
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC55726/ https://ncbi.nlm.nih.gov/pubmed/11410677 |
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