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The J Domain of Papovaviral Large Tumor Antigen Is Required for Synergistic Interaction with the POU-Domain Protein Tst-1/Oct6/SCIP

Large T antigens from polyomaviruses are multifunctional proteins with roles in transcriptional regulation, viral DNA replication, and cellular transformation. They have been shown to enhance the activity of various cellular transcription factors. In the case of the POU protein Tst-1/Oct6/SCIP, this...

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Auteurs principaux:	Sock, Elisabeth, Enderich, Janna, Wegner, Michael, Lin, Rongtuan, Mamane, Yael, Hiscott, John, Cuddihy, Andrew R., Li, Suiyang, Tam, Nancy Wai Ning, Wong, Andrew Hoi-Tao, Taya, Yoichi, Abraham, Ninan, Bell, John C., Koromilas, Antonis E., Schwab, Markus S., Kim, Sang H., Terada, Naohiro, Edfjäll, Catarina, Kozma, Sara C., Thomas, George, Maller, James L., Datto, Michael B., Frederick, Joshua P., Pan, Lihua, Borton, Anita J., Zhuang, Yuan, Wang, Xiao-Fan, Kim-Ha, Jeongsil, Kim, Juri, Kim, Young-Joon, Clarke, Astrid S., Lowell, Joanna E., Jacobson, Sandra J., Pillus, Lorraine, Hautbergue, Guillaume, Goguel, Valérie, Berry, Lynne D., Feoktistova, Anna, Wright, Melanie D., Gould, Kathleen L., Meriin, Anatoli B., Yaglom, Julia A., Gabai, Vladimir L., Mosser, Dick D., Zon, Leonard, Sherman, Michael Y., Khosla, Sanjeev, Aitchison, Alan, Gregory, Richard, Allen, Nicholas D., Feil, Robert, Tremblay, Jacques J., Drouin, Jacques, Biesiada, Elzbieta, Hamamori, Yasuo, Kedes, Larry, Sartorelli, Vittorio, Labhart, Paul, Elkeles, Adi, Juven-Gershon, Tamar, Israeli, David, Wilder, Sylvia, Zalcenstein, Amir, Oren, Moshe, Lauring, Josh, Schlissel, Mark S., Ellwood, Katharine, Huang, Weibiao, Johnson, Reid, Carey, Michael, Sevilla, Lidia, Aperlo, Christel, Dulic, Vjekoslav, Chambard, Jean Claude, Boutonnet, Christel, Pasquier, Olivier, Pognonec, Philippe, Boulukos, Kim E., Brehm, A., Ohbo, K., Zwerschke, W., Botquin, V., Jansen-Dürr, P., Schöler, H. R., Miyamoto, Takahide, Kakizawa, Tomoko, Hashizume, Kiyoshi, Grant, Chris M., Quinn, Kathryn A., Dawes, Ian W., Muro, Andrés F., Caputi, Massimo, Pariyarath, Rajalakshmi, Pagani, Franco, Buratti, Emanuele, Baralle, Francisco E., Sheffer, Ayelet, Varon, Mazal, Choder, Mordechai, Rusterholz, Corinne, Henrioud, Patricia Corthésy, Nabholz, Markus, Hinz, Michael, Krappmann, Daniel, Eichten, Alexandra, Heder, Andreas, Scheidereit, Claus, Strauss, Michael, Southby, Justine, Gooding, Clare, Smith, Christopher W. J., Safak, Mahmut, Gallia, Gary L., Khalili, Kamel, Murphy, Daniel J., Hardy, Stephen, Engel, Daniel A., Pipaón, Carlos, Tsai, Sophia Y., Tsai, Ming-Jer, Sheppard, Hilary M., Corneillie, Siska I., Espiritu, Christine, Gatti, Andrea, Liu, Xuan, Kuribara, Ryoko, Kinoshita, Taisei, Miyajima, Atsushi, Shinjyo, Tetsuharu, Yoshihara, Takao, Inukai, Takeshi, Ozawa, Keiya, Look, A. Thomas, Inaba, Toshiya, Viñals, Francesc, Pouysségur, Jacques, Sikes, Michael L., Suarez, Cristina C., Oltz, Eugene M., Ségault, Véronique, Will, Cindy L., Polycarpou-Schwarz, Maria, Mattaj, Iain W., Branlant, Christiane, Lührmann, Reinhard, Zhai, Weiguo, Comai, Lucio, Bonnefoy, Eliette, Bandu, Marie-Thérèse, Doly, Janine, Haswell, Elizabeth S., O’Shea, Erin K., Nakagawa, Kazumi, Tamai, Katsuyuki, Yamaizumi, Masaru, Muldrow, Tamara A., Campbell, Allyson M., Weil, P. Anthony, Auble, David T., Solow, Steven P., Lezina, Larissa, Lieberman, Paul M., Wilson-Rawls, Jeanne, Molkentin, Jeffery D., Black, Brian L., Olson, Eric N., Chen, Dan, Zhou, Qiang, Tuan, JoAnn C., Ghosh, Asish K., Steele, Robert, Ray, Ratna B., Ye, Amanda J., Haynes, W. John, Romero, Daniel P., Nunes, Alvaro, Thathy, Vandana, Bruderer, Thomas, Sultan, Ali A., Nussenzweig, Ruth S., Ménard, Robert, Perez-Villar, Juan J., Whitney, Gena S., Bowen, Michael A., Hewgill, Derek H., Aruffo, Alejandro A., Kanner, Steven B., Milocco, Lawrence H., Haslam, Jennifer A., Rosen, Jonathan, Seidel, H. Martin, Romanelli, Angela, Martin, Kathleen A., Toker, Alex, Blenis, John, Swanson, Rebecca L., Morey, Natalie J., Doetsch, Paul W., Jinks-Robertson, Sue
Format:	Article
Langue:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publié:	American Society for Microbiology 1999
Sujets:	Transcriptional Regulation Cell Growth and Development DNA Dynamics and Chromosome Structure Gene Expression
Accès en ligne:	https://ncbi.nlm.nih.gov/pmc/articles/PMC84038/ https://ncbi.nlm.nih.gov/pubmed/10082511 https://ncbi.nlm.nih.gov/pmc/articles/PMC84039/ https://ncbi.nlm.nih.gov/pubmed/10082512 https://ncbi.nlm.nih.gov/pmc/articles/PMC84040/ https://ncbi.nlm.nih.gov/pubmed/10082513 https://ncbi.nlm.nih.gov/pmc/articles/PMC84041/ https://ncbi.nlm.nih.gov/pubmed/10082514 https://ncbi.nlm.nih.gov/pmc/articles/PMC84042/ https://ncbi.nlm.nih.gov/pubmed/10082515 https://ncbi.nlm.nih.gov/pmc/articles/PMC84043/ https://ncbi.nlm.nih.gov/pubmed/10082516 https://ncbi.nlm.nih.gov/pmc/articles/PMC84044/ https://ncbi.nlm.nih.gov/pubmed/10082517 https://ncbi.nlm.nih.gov/pmc/articles/PMC84045/ https://ncbi.nlm.nih.gov/pubmed/10082518 https://ncbi.nlm.nih.gov/pmc/articles/PMC84046/ https://ncbi.nlm.nih.gov/pubmed/10082519 https://ncbi.nlm.nih.gov/pmc/articles/PMC84047/ https://ncbi.nlm.nih.gov/pubmed/10082520 https://ncbi.nlm.nih.gov/pmc/articles/PMC84048/ https://ncbi.nlm.nih.gov/pubmed/10082521 https://ncbi.nlm.nih.gov/pmc/articles/PMC84049/ https://ncbi.nlm.nih.gov/pubmed/10082522 https://ncbi.nlm.nih.gov/pmc/articles/PMC84050/ https://ncbi.nlm.nih.gov/pubmed/10082523 https://ncbi.nlm.nih.gov/pmc/articles/PMC84051/ https://ncbi.nlm.nih.gov/pubmed/10082524 https://ncbi.nlm.nih.gov/pmc/articles/PMC84052/ https://ncbi.nlm.nih.gov/pubmed/10082525 https://ncbi.nlm.nih.gov/pmc/articles/PMC84053/ https://ncbi.nlm.nih.gov/pubmed/10082526 https://ncbi.nlm.nih.gov/pmc/articles/PMC84054/ https://ncbi.nlm.nih.gov/pubmed/10082527 https://ncbi.nlm.nih.gov/pmc/articles/PMC84055/ https://ncbi.nlm.nih.gov/pubmed/10082528 https://ncbi.nlm.nih.gov/pmc/articles/PMC84056/ https://ncbi.nlm.nih.gov/pubmed/10082529 https://ncbi.nlm.nih.gov/pmc/articles/PMC84057/ https://ncbi.nlm.nih.gov/pubmed/10082530 https://ncbi.nlm.nih.gov/pmc/articles/PMC84058/ https://ncbi.nlm.nih.gov/pubmed/10082531 https://ncbi.nlm.nih.gov/pmc/articles/PMC84059/ https://ncbi.nlm.nih.gov/pubmed/10082532 https://ncbi.nlm.nih.gov/pmc/articles/PMC84060/ https://ncbi.nlm.nih.gov/pubmed/10082533 https://ncbi.nlm.nih.gov/pmc/articles/PMC84061/ https://ncbi.nlm.nih.gov/pubmed/10082534 https://ncbi.nlm.nih.gov/pmc/articles/PMC84062/ https://ncbi.nlm.nih.gov/pubmed/10082535 https://ncbi.nlm.nih.gov/pmc/articles/PMC84063/ https://ncbi.nlm.nih.gov/pubmed/10082536 https://ncbi.nlm.nih.gov/pmc/articles/PMC84064/ https://ncbi.nlm.nih.gov/pubmed/10082537 https://ncbi.nlm.nih.gov/pmc/articles/PMC84065/ https://ncbi.nlm.nih.gov/pubmed/10082538 https://ncbi.nlm.nih.gov/pmc/articles/PMC84066/ https://ncbi.nlm.nih.gov/pubmed/10082539 https://ncbi.nlm.nih.gov/pmc/articles/PMC84067/ https://ncbi.nlm.nih.gov/pubmed/10082540 https://ncbi.nlm.nih.gov/pmc/articles/PMC84068/ https://ncbi.nlm.nih.gov/pubmed/10082541 https://ncbi.nlm.nih.gov/pmc/articles/PMC84069/ https://ncbi.nlm.nih.gov/pubmed/10082542 https://ncbi.nlm.nih.gov/pmc/articles/PMC84070/ https://ncbi.nlm.nih.gov/pubmed/10082543 https://ncbi.nlm.nih.gov/pmc/articles/PMC84071/ https://ncbi.nlm.nih.gov/pubmed/10082544 https://ncbi.nlm.nih.gov/pmc/articles/PMC84072/ https://ncbi.nlm.nih.gov/pubmed/10082545 https://ncbi.nlm.nih.gov/pmc/articles/PMC84073/ https://ncbi.nlm.nih.gov/pubmed/10082546 https://ncbi.nlm.nih.gov/pmc/articles/PMC84074/ https://ncbi.nlm.nih.gov/pubmed/10082547 https://ncbi.nlm.nih.gov/pmc/articles/PMC84075/ https://ncbi.nlm.nih.gov/pubmed/10082548 https://ncbi.nlm.nih.gov/pmc/articles/PMC84076/ https://ncbi.nlm.nih.gov/pubmed/10082549 https://ncbi.nlm.nih.gov/pmc/articles/PMC84077/ https://ncbi.nlm.nih.gov/pubmed/10082550 https://ncbi.nlm.nih.gov/pmc/articles/PMC84078/ https://ncbi.nlm.nih.gov/pubmed/10082551 https://ncbi.nlm.nih.gov/pmc/articles/PMC84079/ https://ncbi.nlm.nih.gov/pubmed/10082552 https://ncbi.nlm.nih.gov/pmc/articles/PMC84080/ https://ncbi.nlm.nih.gov/pubmed/10082553 https://ncbi.nlm.nih.gov/pmc/articles/PMC84081/ https://ncbi.nlm.nih.gov/pubmed/10082554 https://ncbi.nlm.nih.gov/pmc/articles/PMC84082/ https://ncbi.nlm.nih.gov/pubmed/10082555 https://ncbi.nlm.nih.gov/pmc/articles/PMC84083/ https://ncbi.nlm.nih.gov/pubmed/10082556 https://ncbi.nlm.nih.gov/pmc/articles/PMC84084/ https://ncbi.nlm.nih.gov/pubmed/10082557 https://ncbi.nlm.nih.gov/pmc/articles/PMC84085/ https://ncbi.nlm.nih.gov/pubmed/10082558 https://ncbi.nlm.nih.gov/pmc/articles/PMC84086/ https://ncbi.nlm.nih.gov/pubmed/10082559 https://ncbi.nlm.nih.gov/pmc/articles/PMC84087/ https://ncbi.nlm.nih.gov/pubmed/10082560
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Description
Résumé:	Large T antigens from polyomaviruses are multifunctional proteins with roles in transcriptional regulation, viral DNA replication, and cellular transformation. They have been shown to enhance the activity of various cellular transcription factors. In the case of the POU protein Tst-1/Oct6/SCIP, this enhancement involves a direct physical interaction between the POU domain of the transcription factor and the amino-terminal region of large T antigen. Here we have analyzed the structural requirements for synergistic interaction between the two proteins in greater detail. Tst-1/Oct6/SCIP and the related POU protein Brn-1 were both capable of direct physical interaction with large T antigen. Nevertheless, only Tst-1/Oct6/SCIP functioned synergistically with large T antigen. This differential behavior was due to differences in the amino-terminal regions of the proteins, as evident from chimeras between Tst-1/Oct6/SCIP and Brn-1. Synergy was specifically observed for constructs containing the amino-terminal region of Tst-1/Oct6/SCIP. Large T antigen, on the other hand, functioned synergistically with Tst-1/Oct6/SCIP only when the integrity of its J-domain-containing amino terminus was maintained. Mutations that disrupted the J domain concomitantly abolished the ability to enhance the function of Tst-1/Oct6/SCIP. The J domain of T antigen was also responsible for the physical interaction with Tst-1/Oct6/SCIP and could be replaced in this property by other J domains. Intriguingly, a heterologous J domain from a human DnaJ protein partially substituted for the amino terminus of T antigen even with regard to the synergistic enhancement of Tst-1/Oct6/SCIP function. Given the general role of J domains, we propose chaperone activity as the underlying mechanism for synergy between Tst-1/Oct6/SCIP and large T antigens.

The J Domain of Papovaviral Large Tumor Antigen Is Required for Synergistic Interaction with the POU-Domain Protein Tst-1/Oct6/SCIP

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