Comparative Toxicities and Pharmacokinetics of Intrathecal Lipid (Amphotericin B Colloidal Dispersion) and Conventional Deoxycholate Formulations of Amphotericin B in Rabbits

The lipid formulation of amphotericin B, Amphotec (ABCD), has not been used intrathecally. After a single intrathecal dose or after four doses, conventionally formulated deoxycholate amphotericin B (AMB) (Fungizone) resulted in higher levels of amphotericin B in the cerebrospinal fluid of rabbits th...

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Autori principali: Clemons, Karl V., Sobel, Raymond A., Williams, Paul L., Stevens, David A.
Natura: Articolo
Lingua:en
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC90337/
https://ncbi.nlm.nih.gov/pubmed/11158765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.2.612-615.2001
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spelling pubmed-903372002-09-12 Comparative Toxicities and Pharmacokinetics of Intrathecal Lipid (Amphotericin B Colloidal Dispersion) and Conventional Deoxycholate Formulations of Amphotericin B in Rabbits Clemons, Karl V. Sobel, Raymond A. Williams, Paul L. Stevens, David A. Antimicrob Agents Chemother Pharmacology The lipid formulation of amphotericin B, Amphotec (ABCD), has not been used intrathecally. After a single intrathecal dose or after four doses, conventionally formulated deoxycholate amphotericin B (AMB) (Fungizone) resulted in higher levels of amphotericin B in the cerebrospinal fluid of rabbits than did ABCD. Clinically and histologically, ABCD was about threefold less toxic than AMB after a single dose and 3- to 30-fold less toxic after multiple dosing. These data are encouraging for the potential use of ABCD as an intrathecal treatment. American Society for Microbiology 2001-02 /pmc/articles/PMC90337/ /pubmed/11158765 http://dx.doi.org/10.1128/AAC.45.2.612-615.2001 Text en Copyright © 2001, American Society for Microbiology
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Pharmacology
spellingShingle Pharmacology
Clemons, Karl V.
Sobel, Raymond A.
Williams, Paul L.
Stevens, David A.
Comparative Toxicities and Pharmacokinetics of Intrathecal Lipid (Amphotericin B Colloidal Dispersion) and Conventional Deoxycholate Formulations of Amphotericin B in Rabbits
description The lipid formulation of amphotericin B, Amphotec (ABCD), has not been used intrathecally. After a single intrathecal dose or after four doses, conventionally formulated deoxycholate amphotericin B (AMB) (Fungizone) resulted in higher levels of amphotericin B in the cerebrospinal fluid of rabbits than did ABCD. Clinically and histologically, ABCD was about threefold less toxic than AMB after a single dose and 3- to 30-fold less toxic after multiple dosing. These data are encouraging for the potential use of ABCD as an intrathecal treatment.
author Clemons, Karl V.
Sobel, Raymond A.
Williams, Paul L.
Stevens, David A.
author_facet Clemons, Karl V.
Sobel, Raymond A.
Williams, Paul L.
Stevens, David A.
author_sort Clemons, Karl V.
title Comparative Toxicities and Pharmacokinetics of Intrathecal Lipid (Amphotericin B Colloidal Dispersion) and Conventional Deoxycholate Formulations of Amphotericin B in Rabbits
title_short Comparative Toxicities and Pharmacokinetics of Intrathecal Lipid (Amphotericin B Colloidal Dispersion) and Conventional Deoxycholate Formulations of Amphotericin B in Rabbits
title_full Comparative Toxicities and Pharmacokinetics of Intrathecal Lipid (Amphotericin B Colloidal Dispersion) and Conventional Deoxycholate Formulations of Amphotericin B in Rabbits
title_fullStr Comparative Toxicities and Pharmacokinetics of Intrathecal Lipid (Amphotericin B Colloidal Dispersion) and Conventional Deoxycholate Formulations of Amphotericin B in Rabbits
title_full_unstemmed Comparative Toxicities and Pharmacokinetics of Intrathecal Lipid (Amphotericin B Colloidal Dispersion) and Conventional Deoxycholate Formulations of Amphotericin B in Rabbits
title_sort comparative toxicities and pharmacokinetics of intrathecal lipid (amphotericin b colloidal dispersion) and conventional deoxycholate formulations of amphotericin b in rabbits
publisher American Society for Microbiology
publisher_facet American Society for Microbiology
publishDate 2001
url https://ncbi.nlm.nih.gov/pmc/articles/PMC90337/
https://ncbi.nlm.nih.gov/pubmed/11158765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.2.612-615.2001
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