Antioxidant Functions Required for Insusceptibility of Saccharomyces cerevisiae to Tetracycline Antibiotics

Cu,Zn superoxide dismutase (Sod1) is required for insusceptibility of Saccharomyces cerevisiae to oxytetracycline (OTC). Here we report that Sod1 is also required for insusceptibility to doxycycline (DOX). Furthermore, among a range of antioxidant and redox balance mutants, mac1 and ctr1 deletion st...

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Main Authors: Angrave, Fiona E., Avery, Simon V.
Formato: Artigo
Idioma:en
Publicado em: American Society for Microbiology 2001
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90759/
https://ncbi.nlm.nih.gov/pubmed/11557497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.10.2939-2942.2001
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spelling pubmed-907592002-09-12 Antioxidant Functions Required for Insusceptibility of Saccharomyces cerevisiae to Tetracycline Antibiotics Angrave, Fiona E. Avery, Simon V. Antimicrob Agents Chemother Mechanisms of Action: Physiological Effects Cu,Zn superoxide dismutase (Sod1) is required for insusceptibility of Saccharomyces cerevisiae to oxytetracycline (OTC). Here we report that Sod1 is also required for insusceptibility to doxycycline (DOX). Furthermore, among a range of antioxidant and redox balance mutants, mac1 and ctr1 deletion strains exhibited marked sensitization to OTC and DOX. Certain mutants exhibited a slight sensitivity to methacycline and minocycline. Addition of copper suppressed antibiotic sensitivity. Thus, intracellular copper as well as superoxide dismutase can be critical for eukaryotic tolerance of several tetracycline antibiotics. American Society for Microbiology 2001-10 /pmc/articles/PMC90759/ /pubmed/11557497 http://dx.doi.org/10.1128/AAC.45.10.2939-2942.2001 Text en Copyright © 2001, American Society for Microbiology
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Mechanisms of Action: Physiological Effects
spellingShingle Mechanisms of Action: Physiological Effects
Angrave, Fiona E.
Avery, Simon V.
Antioxidant Functions Required for Insusceptibility of Saccharomyces cerevisiae to Tetracycline Antibiotics
description Cu,Zn superoxide dismutase (Sod1) is required for insusceptibility of Saccharomyces cerevisiae to oxytetracycline (OTC). Here we report that Sod1 is also required for insusceptibility to doxycycline (DOX). Furthermore, among a range of antioxidant and redox balance mutants, mac1 and ctr1 deletion strains exhibited marked sensitization to OTC and DOX. Certain mutants exhibited a slight sensitivity to methacycline and minocycline. Addition of copper suppressed antibiotic sensitivity. Thus, intracellular copper as well as superoxide dismutase can be critical for eukaryotic tolerance of several tetracycline antibiotics.
author Angrave, Fiona E.
Avery, Simon V.
author_facet Angrave, Fiona E.
Avery, Simon V.
author_sort Angrave, Fiona E.
title Antioxidant Functions Required for Insusceptibility of Saccharomyces cerevisiae to Tetracycline Antibiotics
title_short Antioxidant Functions Required for Insusceptibility of Saccharomyces cerevisiae to Tetracycline Antibiotics
title_full Antioxidant Functions Required for Insusceptibility of Saccharomyces cerevisiae to Tetracycline Antibiotics
title_fullStr Antioxidant Functions Required for Insusceptibility of Saccharomyces cerevisiae to Tetracycline Antibiotics
title_full_unstemmed Antioxidant Functions Required for Insusceptibility of Saccharomyces cerevisiae to Tetracycline Antibiotics
title_sort antioxidant functions required for insusceptibility of saccharomyces cerevisiae to tetracycline antibiotics
publisher American Society for Microbiology
publisher_facet American Society for Microbiology
publishDate 2001
url https://ncbi.nlm.nih.gov/pmc/articles/PMC90759/
https://ncbi.nlm.nih.gov/pubmed/11557497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.10.2939-2942.2001
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