In Vitro Activity of PNU-100766 (Linezolid), a New Oxazolidinone Antimicrobial, against Nocardia brasiliensis

The in vitro activity of a novel oxazolidinone, linezolid, was studied by comparing the activity of linezolid with those of amikacin, trimethoprim-sulfamethoxazole, and amoxicillin-clavulanic acid against 25 strains of Nocardia brasiliensis isolated from patients with mycetoma. All N. brasiliensis s...

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Main Authors: Vera-Cabrera, Lucio, Gómez-Flores, Alejandra, Escalante-Fuentes, Wendy G., Welsh, Oliverio
Formato: Artigo
Idioma:en
Publicado em: American Society for Microbiology 2001
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90885/
https://ncbi.nlm.nih.gov/pubmed/11709356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.12.3629-3630.2001
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spelling pubmed-908852002-09-12 In Vitro Activity of PNU-100766 (Linezolid), a New Oxazolidinone Antimicrobial, against Nocardia brasiliensis Vera-Cabrera, Lucio Gómez-Flores, Alejandra Escalante-Fuentes, Wendy G. Welsh, Oliverio Antimicrob Agents Chemother Susceptibility The in vitro activity of a novel oxazolidinone, linezolid, was studied by comparing the activity of linezolid with those of amikacin, trimethoprim-sulfamethoxazole, and amoxicillin-clavulanic acid against 25 strains of Nocardia brasiliensis isolated from patients with mycetoma. All N. brasiliensis strains tested were sensitive to linezolid (MIC at which 90% of strains are inhibited [MIC(90)], 2 μg/ml; MIC(50), 1 μg/ml). This antimicrobial might constitute a good alternative for treatment of actinomycetoma. American Society for Microbiology 2001-12 /pmc/articles/PMC90885/ /pubmed/11709356 http://dx.doi.org/10.1128/AAC.45.12.3629-3630.2001 Text en Copyright © 2001, American Society for Microbiology
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Susceptibility
spellingShingle Susceptibility
Vera-Cabrera, Lucio
Gómez-Flores, Alejandra
Escalante-Fuentes, Wendy G.
Welsh, Oliverio
In Vitro Activity of PNU-100766 (Linezolid), a New Oxazolidinone Antimicrobial, against Nocardia brasiliensis
description The in vitro activity of a novel oxazolidinone, linezolid, was studied by comparing the activity of linezolid with those of amikacin, trimethoprim-sulfamethoxazole, and amoxicillin-clavulanic acid against 25 strains of Nocardia brasiliensis isolated from patients with mycetoma. All N. brasiliensis strains tested were sensitive to linezolid (MIC at which 90% of strains are inhibited [MIC(90)], 2 μg/ml; MIC(50), 1 μg/ml). This antimicrobial might constitute a good alternative for treatment of actinomycetoma.
author Vera-Cabrera, Lucio
Gómez-Flores, Alejandra
Escalante-Fuentes, Wendy G.
Welsh, Oliverio
author_facet Vera-Cabrera, Lucio
Gómez-Flores, Alejandra
Escalante-Fuentes, Wendy G.
Welsh, Oliverio
author_sort Vera-Cabrera, Lucio
title In Vitro Activity of PNU-100766 (Linezolid), a New Oxazolidinone Antimicrobial, against Nocardia brasiliensis
title_short In Vitro Activity of PNU-100766 (Linezolid), a New Oxazolidinone Antimicrobial, against Nocardia brasiliensis
title_full In Vitro Activity of PNU-100766 (Linezolid), a New Oxazolidinone Antimicrobial, against Nocardia brasiliensis
title_fullStr In Vitro Activity of PNU-100766 (Linezolid), a New Oxazolidinone Antimicrobial, against Nocardia brasiliensis
title_full_unstemmed In Vitro Activity of PNU-100766 (Linezolid), a New Oxazolidinone Antimicrobial, against Nocardia brasiliensis
title_sort in vitro activity of pnu-100766 (linezolid), a new oxazolidinone antimicrobial, against nocardia brasiliensis
publisher American Society for Microbiology
publisher_facet American Society for Microbiology
publishDate 2001
url https://ncbi.nlm.nih.gov/pmc/articles/PMC90885/
https://ncbi.nlm.nih.gov/pubmed/11709356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.12.3629-3630.2001
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