Theileria annulata in CD5(+) Macrophages and B1 B Cells

Theileria parasites infect and transform bovine leukocytes. We have analyzed laboratory-established Theileria sp.-infected leukocyte lines and observed that transformed macrophages express CD5. Low-level expression of CD5 by macrophages was further confirmed on three independent Theileria annulata c...

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Autori principali: Moreau, Marie-Françoise, Thibaud, Jean-Laurent, Miled, Leila Ben, Chaussepied, Marie, Baumgartner, Martin, Davis, William C., Minoprio, Paola, Langsley, Gordon
Natura: Articolo
Lingua:en
Pubblicazione: American Society for Microbiology (ASM) 1999
Soggetti:
Fungal and Parasitic Infections
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC97082/
https://ncbi.nlm.nih.gov/pubmed/10569790
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spelling pubmed-970822002-09-12 Theileria annulata in CD5(+) Macrophages and B1 B Cells Moreau, Marie-Françoise Thibaud, Jean-Laurent Miled, Leila Ben Chaussepied, Marie Baumgartner, Martin Davis, William C. Minoprio, Paola Langsley, Gordon Infect Immun Fungal and Parasitic Infections Theileria parasites infect and transform bovine leukocytes. We have analyzed laboratory-established Theileria sp.-infected leukocyte lines and observed that transformed macrophages express CD5. Low-level expression of CD5 by macrophages was further confirmed on three independent Theileria annulata clinical isolates from Tunisia. Interestingly, the fourth CD5(+) clinical isolate (MB2) was morphologically different, expressed surface immunoglobulin M (IgM) and BoLA class II, and had rearranged Ig light-chain genes. To demonstrate that MB2 did indeed contain CD5(+) B cells, individual clonal lines were obtained by limiting dilution, and CD5 expression and Ig gene rearrangement were confirmed. This suggests that in natural infections T. annulata can invade and transform CD5(+) B cells. American Society for Microbiology (ASM) 1999-12 /pmc/articles/PMC97082/ /pubmed/10569790 Text en Copyright © 1999, American Society for Microbiology
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Fungal and Parasitic Infections
spellingShingle Fungal and Parasitic Infections
Moreau, Marie-Françoise
Thibaud, Jean-Laurent
Miled, Leila Ben
Chaussepied, Marie
Baumgartner, Martin
Davis, William C.
Minoprio, Paola
Langsley, Gordon
Theileria annulata in CD5(+) Macrophages and B1 B Cells
description Theileria parasites infect and transform bovine leukocytes. We have analyzed laboratory-established Theileria sp.-infected leukocyte lines and observed that transformed macrophages express CD5. Low-level expression of CD5 by macrophages was further confirmed on three independent Theileria annulata clinical isolates from Tunisia. Interestingly, the fourth CD5(+) clinical isolate (MB2) was morphologically different, expressed surface immunoglobulin M (IgM) and BoLA class II, and had rearranged Ig light-chain genes. To demonstrate that MB2 did indeed contain CD5(+) B cells, individual clonal lines were obtained by limiting dilution, and CD5 expression and Ig gene rearrangement were confirmed. This suggests that in natural infections T. annulata can invade and transform CD5(+) B cells.
author Moreau, Marie-Françoise
Thibaud, Jean-Laurent
Miled, Leila Ben
Chaussepied, Marie
Baumgartner, Martin
Davis, William C.
Minoprio, Paola
Langsley, Gordon
author_facet Moreau, Marie-Françoise
Thibaud, Jean-Laurent
Miled, Leila Ben
Chaussepied, Marie
Baumgartner, Martin
Davis, William C.
Minoprio, Paola
Langsley, Gordon
author_sort Moreau, Marie-Françoise
title Theileria annulata in CD5(+) Macrophages and B1 B Cells
title_short Theileria annulata in CD5(+) Macrophages and B1 B Cells
title_full Theileria annulata in CD5(+) Macrophages and B1 B Cells
title_fullStr Theileria annulata in CD5(+) Macrophages and B1 B Cells
title_full_unstemmed Theileria annulata in CD5(+) Macrophages and B1 B Cells
title_sort theileria annulata in cd5(+) macrophages and b1 b cells
publisher American Society for Microbiology (ASM)
publisher_facet American Society for Microbiology (ASM)
publishDate 1999
url https://ncbi.nlm.nih.gov/pmc/articles/PMC97082/
https://ncbi.nlm.nih.gov/pubmed/10569790
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