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A Model of Infected Burn Wounds Using Escherichia coli O18:K1:H7 for the Study of Gram-Negative Bacteremia and Sepsis
A difficulty that has emerged in the development and preclinical evaluation of adjuvant therapies for gram-negative sepsis is the lack of easily studied animal models that closely mimic human infection. An objective of this study was to adapt a previously described model of infection in burned mice...
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pubmed-97598 |
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pubmed-975982002-09-12 A Model of Infected Burn Wounds Using Escherichia coli O18:K1:H7 for the Study of Gram-Negative Bacteremia and Sepsis Busch, Nathan A. Zanzot, Emily M. Loiselle, Paul M. Carter, Edward A. Allaire, Jennifer E. Yarmush, Martin L. Warren, H. Shaw Infect Immun Bacterial Infections A difficulty that has emerged in the development and preclinical evaluation of adjuvant therapies for gram-negative sepsis is the lack of easily studied animal models that closely mimic human infection. An objective of this study was to adapt a previously described model of infection in burned mice to rats with a defined bacterial strain of Escherichia coli. Challenge with two colonies of live E. coli O18:K1:H7 bacteria into an 8% full-thickness burn of the dorsal skin surface of rats produced predictable bacteremia at 24 to 48 h and 80 to 100% mortality at 3 to 4 days. E. coli O18:K1:H7 was approximately 10-million-fold more virulent than several other gram-negative bacterial strains. The model should be a useful tool in studying the pathogenicity of burn wound infections and in evaluating the efficacy of novel adjuvant therapies for gram-negative sepsis. American Society for Microbiology 2000-06 /pmc/articles/PMC97598/ /pubmed/10816484 Text en Copyright © 2000, American Society for Microbiology |
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US National Library of Medicine |
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PubMed Central |
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English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English |
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Article |
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Bacterial Infections Article Molecular and Cellular Pathogenesis Article Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Article Fungal and Parasitic Infections Article Fungal and Parasitic Infections Article Article Host Response and Inflammation Article Fungal and Parasitic Infections Host Response and Inflammation Article Article Molecular and Cellular Pathogenesis Article Host Response and Inflammation Molecular and Cellular Pathogenesis Article Molecular and Cellular Pathogenesis Microbial Immunity and Vaccines Article Fungal and Parasitic Infections Article Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis NAR Methods Online NAR Methods Online Molecular and Cellular Pathogenesis NAR Methods Online Fungal and Parasitic Infections NAR Methods Online Molecular Genomics Host Response and Inflammation Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Fungal and Parasitic Infections Molecular and Cellular Pathogenesis Fungal and Parasitic Infections Host Response and Inflammation Bacterial Infections |
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Bacterial Infections Article Molecular and Cellular Pathogenesis Article Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Article Fungal and Parasitic Infections Article Fungal and Parasitic Infections Article Article Host Response and Inflammation Article Fungal and Parasitic Infections Host Response and Inflammation Article Article Molecular and Cellular Pathogenesis Article Host Response and Inflammation Molecular and Cellular Pathogenesis Article Molecular and Cellular Pathogenesis Microbial Immunity and Vaccines Article Fungal and Parasitic Infections Article Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis NAR Methods Online NAR Methods Online Molecular and Cellular Pathogenesis NAR Methods Online Fungal and Parasitic Infections NAR Methods Online Molecular Genomics Host Response and Inflammation Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Molecular and Cellular Pathogenesis Fungal and Parasitic Infections Molecular and Cellular Pathogenesis Fungal and Parasitic Infections Host Response and Inflammation Bacterial Infections Busch, Nathan A. Zanzot, Emily M. Loiselle, Paul M. Carter, Edward A. Allaire, Jennifer E. Yarmush, Martin L. Warren, H. Shaw Verbeure, Birgit Lescrinier, Eveline Wang, Jing Herdewijn, Piet Filiatrault, Melanie J. Gibson, Bradford W. Schilling, Birgit Sun, Shuhua Munson, Robert S. Campagnari, Anthony A. Kim, Yoon Ki Back, Sung Hoon Rho, Jungmin Lee, Song Hee Jang, Sung Key Kubiet, Martin Ramphal, Reuben Weber, Allan Smith, Arnold Klein, Joanna R. Fahlen, Thomas F. Jones, Bradley D. van Beekvelt, Catelijne A. de Graaff-Vincent, Muriel Faber, Alex W. van ’t Riet, Jan Venema, Jaap Raué, Hendrik A. Wasylnka, Julie A. Moore, Margo M. Chatterjee, Aditi Singh, Keshav K. Asahi, Hiroko Osman, Ahmed Cook, Rosemary M. LoVerde, Philip T. Stadecker, Miguel J. Sriskanda, Verl Shuman, Stewart Datta, Hirock J. Glazer, Peter M. Kim, Hyung-Yong Rikihisa, Yasuko Jones, Fatima D. Ryder, Sean P. Strobel, Scott A. Franke, Eileen D. Sette, Alessandro Sacci, John Southwood, Scott Corradin, Giampietro Hoffman, Stephen L. Scott, K. G.-E. Logan, M. R. Klammer, G. M. Teoh, D. A. Buret, A. G. Gray, Misa Honigberg, Saul M. Sclimenti, Christopher R. Thyagarajan, Bhaskar Calos, Michele P. Oyston, Petra C. F. Dorrell, Nick Williams, Kerstin Li, Shu-Rui Green, Michael Titball, Richard W. Wren, Brendan W. Hudakova, Sabina Michalek, Wolfgang Presting, Gernot G. Hoopen, Rogier ten Santos, Karla dos Jasencakova, Zuzana Schubert, Ingo Halonen, Sandra K. Weiss, Louis M. Peiffer, Isabelle Blanc-Potard, Anne-Béatrice Bernet-Camard, Marie-Françoise Guignot, Julie Barbat, Alain Servin, Alain L. Ozoline, Olga N. Fujita, Nobuyuki Ishihama, Akira Jarosik, Gregory P. Land, Carol Beth Yamaguchi, Hiroyuki Osaki, Takako Kai, Masanori Taguchi, Haruhiko Kamiya, Shigeru Adam, Waldemar Arnold, Markus A. Nau, Werner M. Pischel, Uwe Saha-Möller, Chantu R. Rogers, Nicola J. Hall, Belinda S. Obiero, Jacktone Targett, Geoffrey A. T. Sutherland, Colin J. Wuyts, Jan Peer, Yves Van de Wachter, Rupert De Boyce, John D. Adler, Ben Billson, F. Mark Harbour, Colin Michalski, Wojtek P. Tennent, Jan M. Egerton, John R. Hodgson, Jennifer L. Kesminiene, A. Maneliene, Z. Vitkute, J. Petruyte, M. Janulaitis, A. Ahmadian, Afshin Gharizadeh, Baback O’Meara, Deirdre Odeberg, Jacob Lundeberg, Joakim Stiles, Bradley G. Hale, Martha L. Marvaud, Jean-Christophe Popoff, Michel R. Henn, Arnon Halfon, Jacob Kela, Itai Orion, Itzhak Sagi, Irit Phan, Quynh T. Belanger, Paul H. Filler, Scott G. Brock, Graham J. R. Huang, Tim Hui-Ming Chen, Chuan-Mu Johnson, Keith J. Lizotte-Waniewski, Michelle Tawe, Wilson Guiliano, David B. Lu, Wenhong Liu, Jing Williams, Steven A. Lustigman, Sara Hochholzer, Peter Lipford, Grayson B. Wagner, Hermann Pfeffer, Klaus Heeg, Klaus Sun, Ronggai Anderson, Timothy J. Erickson, Alan K. Nelson, Eric A. Francis, David H. Que, Yok-Ai Haefliger, Jacques-Antoine Francioli, Patrick Moreillon, Philippe Chatellier, Sonia Ihendyane, Nahla Kansal, Rita G. Khambaty, Farukh Basma, Hesham Norrby-Teglund, Anna Low, Donald E. McGeer, Allison Kotb, Malak Šimelyte, Egle Rimpiläinen, Marja Lehtonen, Leena Zhang, Xiang Toivanen, Paavo Khan, A. Salam Kniep, Bernhard Oelschlaeger, Tobias A. Van Die, Irma Korhonen, Timo Hacker, Jörg Bayer, Arnold S. Prasad, Rajendra Chandra, Jyotsna Koul, Anjni Smriti, M. Varma, Archana Skurray, Ronald A. Firth, Neville Brown, Melissa H. Koo, Su-Pin Yeaman, Michael R. Guignot, Julie Peiffer, Isabelle Bernet-Camard, Marie-Françoise Lublin, Douglas M. Carnoy, Christophe Moseley, Steve L. Servin, Alain L. Liang, Hong Narum, David L. Fuhrmann, Steven R. Luu, Tin Sim, B. Kim Lee Shao, Chung-Ping Hor, Lien-I Millar, Amanda E. Kahn, Stuart J. Hessle, Christina Andersson, Bengt Wold, Agnes E. Darrah, Patricia A. Hondalus, Mary K. Chen, Quiping Ischiropoulos, Harry Mosser, David M. A Model of Infected Burn Wounds Using Escherichia coli O18:K1:H7 for the Study of Gram-Negative Bacteremia and Sepsis |
| description |
A difficulty that has emerged in the development and preclinical evaluation of adjuvant therapies for gram-negative sepsis is the lack of easily studied animal models that closely mimic human infection. An objective of this study was to adapt a previously described model of infection in burned mice to rats with a defined bacterial strain of Escherichia coli. Challenge with two colonies of live E. coli O18:K1:H7 bacteria into an 8% full-thickness burn of the dorsal skin surface of rats produced predictable bacteremia at 24 to 48 h and 80 to 100% mortality at 3 to 4 days. E. coli O18:K1:H7 was approximately 10-million-fold more virulent than several other gram-negative bacterial strains. The model should be a useful tool in studying the pathogenicity of burn wound infections and in evaluating the efficacy of novel adjuvant therapies for gram-negative sepsis. |
| author |
Busch, Nathan A. Zanzot, Emily M. Loiselle, Paul M. Carter, Edward A. Allaire, Jennifer E. Yarmush, Martin L. Warren, H. Shaw Verbeure, Birgit Lescrinier, Eveline Wang, Jing Herdewijn, Piet Filiatrault, Melanie J. Gibson, Bradford W. Schilling, Birgit Sun, Shuhua Munson, Robert S. Campagnari, Anthony A. Kim, Yoon Ki Back, Sung Hoon Rho, Jungmin Lee, Song Hee Jang, Sung Key Kubiet, Martin Ramphal, Reuben Weber, Allan Smith, Arnold Klein, Joanna R. Fahlen, Thomas F. Jones, Bradley D. van Beekvelt, Catelijne A. de Graaff-Vincent, Muriel Faber, Alex W. van ’t Riet, Jan Venema, Jaap Raué, Hendrik A. Wasylnka, Julie A. Moore, Margo M. Chatterjee, Aditi Singh, Keshav K. Asahi, Hiroko Osman, Ahmed Cook, Rosemary M. LoVerde, Philip T. Stadecker, Miguel J. Sriskanda, Verl Shuman, Stewart Datta, Hirock J. Glazer, Peter M. Kim, Hyung-Yong Rikihisa, Yasuko Jones, Fatima D. Ryder, Sean P. Strobel, Scott A. Franke, Eileen D. Sette, Alessandro Sacci, John Southwood, Scott Corradin, Giampietro Hoffman, Stephen L. Scott, K. G.-E. Logan, M. R. Klammer, G. M. Teoh, D. A. Buret, A. G. Gray, Misa Honigberg, Saul M. Sclimenti, Christopher R. Thyagarajan, Bhaskar Calos, Michele P. Oyston, Petra C. F. Dorrell, Nick Williams, Kerstin Li, Shu-Rui Green, Michael Titball, Richard W. Wren, Brendan W. Hudakova, Sabina Michalek, Wolfgang Presting, Gernot G. Hoopen, Rogier ten Santos, Karla dos Jasencakova, Zuzana Schubert, Ingo Halonen, Sandra K. Weiss, Louis M. Peiffer, Isabelle Blanc-Potard, Anne-Béatrice Bernet-Camard, Marie-Françoise Guignot, Julie Barbat, Alain Servin, Alain L. Ozoline, Olga N. Fujita, Nobuyuki Ishihama, Akira Jarosik, Gregory P. Land, Carol Beth Yamaguchi, Hiroyuki Osaki, Takako Kai, Masanori Taguchi, Haruhiko Kamiya, Shigeru Adam, Waldemar Arnold, Markus A. Nau, Werner M. Pischel, Uwe Saha-Möller, Chantu R. Rogers, Nicola J. Hall, Belinda S. Obiero, Jacktone Targett, Geoffrey A. T. Sutherland, Colin J. Wuyts, Jan Peer, Yves Van de Wachter, Rupert De Boyce, John D. Adler, Ben Billson, F. Mark Harbour, Colin Michalski, Wojtek P. Tennent, Jan M. Egerton, John R. Hodgson, Jennifer L. Kesminiene, A. Maneliene, Z. Vitkute, J. Petruyte, M. Janulaitis, A. Ahmadian, Afshin Gharizadeh, Baback O’Meara, Deirdre Odeberg, Jacob Lundeberg, Joakim Stiles, Bradley G. Hale, Martha L. Marvaud, Jean-Christophe Popoff, Michel R. Henn, Arnon Halfon, Jacob Kela, Itai Orion, Itzhak Sagi, Irit Phan, Quynh T. Belanger, Paul H. Filler, Scott G. Brock, Graham J. R. Huang, Tim Hui-Ming Chen, Chuan-Mu Johnson, Keith J. Lizotte-Waniewski, Michelle Tawe, Wilson Guiliano, David B. Lu, Wenhong Liu, Jing Williams, Steven A. Lustigman, Sara Hochholzer, Peter Lipford, Grayson B. Wagner, Hermann Pfeffer, Klaus Heeg, Klaus Sun, Ronggai Anderson, Timothy J. Erickson, Alan K. Nelson, Eric A. Francis, David H. Que, Yok-Ai Haefliger, Jacques-Antoine Francioli, Patrick Moreillon, Philippe Chatellier, Sonia Ihendyane, Nahla Kansal, Rita G. Khambaty, Farukh Basma, Hesham Norrby-Teglund, Anna Low, Donald E. McGeer, Allison Kotb, Malak Šimelyte, Egle Rimpiläinen, Marja Lehtonen, Leena Zhang, Xiang Toivanen, Paavo Khan, A. Salam Kniep, Bernhard Oelschlaeger, Tobias A. Van Die, Irma Korhonen, Timo Hacker, Jörg Bayer, Arnold S. Prasad, Rajendra Chandra, Jyotsna Koul, Anjni Smriti, M. Varma, Archana Skurray, Ronald A. Firth, Neville Brown, Melissa H. Koo, Su-Pin Yeaman, Michael R. Guignot, Julie Peiffer, Isabelle Bernet-Camard, Marie-Françoise Lublin, Douglas M. Carnoy, Christophe Moseley, Steve L. Servin, Alain L. Liang, Hong Narum, David L. Fuhrmann, Steven R. Luu, Tin Sim, B. Kim Lee Shao, Chung-Ping Hor, Lien-I Millar, Amanda E. Kahn, Stuart J. Hessle, Christina Andersson, Bengt Wold, Agnes E. Darrah, Patricia A. Hondalus, Mary K. Chen, Quiping Ischiropoulos, Harry Mosser, David M. |
| author_facet |
Busch, Nathan A. Zanzot, Emily M. Loiselle, Paul M. Carter, Edward A. Allaire, Jennifer E. Yarmush, Martin L. Warren, H. Shaw Verbeure, Birgit Lescrinier, Eveline Wang, Jing Herdewijn, Piet Filiatrault, Melanie J. Gibson, Bradford W. Schilling, Birgit Sun, Shuhua Munson, Robert S. Campagnari, Anthony A. Kim, Yoon Ki Back, Sung Hoon Rho, Jungmin Lee, Song Hee Jang, Sung Key Kubiet, Martin Ramphal, Reuben Weber, Allan Smith, Arnold Klein, Joanna R. Fahlen, Thomas F. Jones, Bradley D. van Beekvelt, Catelijne A. de Graaff-Vincent, Muriel Faber, Alex W. van ’t Riet, Jan Venema, Jaap Raué, Hendrik A. Wasylnka, Julie A. Moore, Margo M. Chatterjee, Aditi Singh, Keshav K. Asahi, Hiroko Osman, Ahmed Cook, Rosemary M. LoVerde, Philip T. Stadecker, Miguel J. Sriskanda, Verl Shuman, Stewart Datta, Hirock J. Glazer, Peter M. Kim, Hyung-Yong Rikihisa, Yasuko Jones, Fatima D. Ryder, Sean P. Strobel, Scott A. Franke, Eileen D. Sette, Alessandro Sacci, John Southwood, Scott Corradin, Giampietro Hoffman, Stephen L. Scott, K. G.-E. Logan, M. R. Klammer, G. M. Teoh, D. A. Buret, A. G. Gray, Misa Honigberg, Saul M. Sclimenti, Christopher R. Thyagarajan, Bhaskar Calos, Michele P. Oyston, Petra C. F. Dorrell, Nick Williams, Kerstin Li, Shu-Rui Green, Michael Titball, Richard W. Wren, Brendan W. Hudakova, Sabina Michalek, Wolfgang Presting, Gernot G. Hoopen, Rogier ten Santos, Karla dos Jasencakova, Zuzana Schubert, Ingo Halonen, Sandra K. Weiss, Louis M. Peiffer, Isabelle Blanc-Potard, Anne-Béatrice Bernet-Camard, Marie-Françoise Guignot, Julie Barbat, Alain Servin, Alain L. Ozoline, Olga N. Fujita, Nobuyuki Ishihama, Akira Jarosik, Gregory P. Land, Carol Beth Yamaguchi, Hiroyuki Osaki, Takako Kai, Masanori Taguchi, Haruhiko Kamiya, Shigeru Adam, Waldemar Arnold, Markus A. Nau, Werner M. Pischel, Uwe Saha-Möller, Chantu R. Rogers, Nicola J. Hall, Belinda S. Obiero, Jacktone Targett, Geoffrey A. T. Sutherland, Colin J. Wuyts, Jan Peer, Yves Van de Wachter, Rupert De Boyce, John D. Adler, Ben Billson, F. Mark Harbour, Colin Michalski, Wojtek P. Tennent, Jan M. Egerton, John R. Hodgson, Jennifer L. Kesminiene, A. Maneliene, Z. Vitkute, J. Petruyte, M. Janulaitis, A. Ahmadian, Afshin Gharizadeh, Baback O’Meara, Deirdre Odeberg, Jacob Lundeberg, Joakim Stiles, Bradley G. Hale, Martha L. Marvaud, Jean-Christophe Popoff, Michel R. Henn, Arnon Halfon, Jacob Kela, Itai Orion, Itzhak Sagi, Irit Phan, Quynh T. Belanger, Paul H. Filler, Scott G. Brock, Graham J. R. Huang, Tim Hui-Ming Chen, Chuan-Mu Johnson, Keith J. Lizotte-Waniewski, Michelle Tawe, Wilson Guiliano, David B. Lu, Wenhong Liu, Jing Williams, Steven A. Lustigman, Sara Hochholzer, Peter Lipford, Grayson B. Wagner, Hermann Pfeffer, Klaus Heeg, Klaus Sun, Ronggai Anderson, Timothy J. Erickson, Alan K. Nelson, Eric A. Francis, David H. Que, Yok-Ai Haefliger, Jacques-Antoine Francioli, Patrick Moreillon, Philippe Chatellier, Sonia Ihendyane, Nahla Kansal, Rita G. Khambaty, Farukh Basma, Hesham Norrby-Teglund, Anna Low, Donald E. McGeer, Allison Kotb, Malak Šimelyte, Egle Rimpiläinen, Marja Lehtonen, Leena Zhang, Xiang Toivanen, Paavo Khan, A. Salam Kniep, Bernhard Oelschlaeger, Tobias A. Van Die, Irma Korhonen, Timo Hacker, Jörg Bayer, Arnold S. Prasad, Rajendra Chandra, Jyotsna Koul, Anjni Smriti, M. Varma, Archana Skurray, Ronald A. Firth, Neville Brown, Melissa H. Koo, Su-Pin Yeaman, Michael R. Guignot, Julie Peiffer, Isabelle Bernet-Camard, Marie-Françoise Lublin, Douglas M. Carnoy, Christophe Moseley, Steve L. Servin, Alain L. Liang, Hong Narum, David L. Fuhrmann, Steven R. Luu, Tin Sim, B. Kim Lee Shao, Chung-Ping Hor, Lien-I Millar, Amanda E. Kahn, Stuart J. Hessle, Christina Andersson, Bengt Wold, Agnes E. Darrah, Patricia A. Hondalus, Mary K. Chen, Quiping Ischiropoulos, Harry Mosser, David M. |
| author_sort |
Busch, Nathan A. |
| title |
A Model of Infected Burn Wounds Using Escherichia coli O18:K1:H7 for the Study of Gram-Negative Bacteremia and Sepsis |
| title_short |
A Model of Infected Burn Wounds Using Escherichia coli O18:K1:H7 for the Study of Gram-Negative Bacteremia and Sepsis |
| title_full |
A Model of Infected Burn Wounds Using Escherichia coli O18:K1:H7 for the Study of Gram-Negative Bacteremia and Sepsis |
| title_fullStr |
A Model of Infected Burn Wounds Using Escherichia coli O18:K1:H7 for the Study of Gram-Negative Bacteremia and Sepsis |
| title_full_unstemmed |
A Model of Infected Burn Wounds Using Escherichia coli O18:K1:H7 for the Study of Gram-Negative Bacteremia and Sepsis |
| title_sort |
model of infected burn wounds using escherichia coli o18:k1:h7 for the study of gram-negative bacteremia and sepsis |
| publisher |
American Society for Microbiology |
| publisher_facet |
American Society for Microbiology |
| publishDate |
2000 |
| url |
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| _version_ |
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