Bibliotecas PUC-SP - Busca Integrada

Influence of denaturants on amyloid β42 aggregation kinetics

por Tanja Weiffert, Georg Meisl, Georg Meisl, Samo Curk, Risto Cukalevski, Anđela Šarić, Tuomas P. J. Knowles, Tuomas P. J. Knowles, Tuomas P. J. Knowles, Sara Linse
Publicado en Frontiers in Neuroscience (2022-09-01)

Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative Disease

por Georg Meisl, Tuomas P. J. Knowles, Tuomas P. J. Knowles, David Klenerman, David Klenerman
Publicado en Frontiers in Neuroscience (2022-06-01)

Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells

por Jason C. Sang, Eric Hidari, Georg Meisl, Rohan T. Ranasinghe, Maria Grazia Spillantini, David Klenerman
Publicado en Communications Biology (2021-05-01)

In situ kinetic measurements of α-synuclein aggregation reveal large population of short-lived oligomers.

por Enrico Zurlo, Pravin Kumar, Georg Meisl, Alexander J Dear, Dipro Mondal, Mireille M A E Claessens, Tuomas P J Knowles, Martina Huber
Publicado en PLoS ONE (2021-01-01)

Physical Determinants of Amyloid Assembly in Biofilm Formation

por Maria Andreasen, Georg Meisl, Jonathan D. Taylor, Thomas C. T. Michaels, Aviad Levin, Daniel E. Otzen, Matthew R. Chapman, Christopher M. Dobson, Steve J. Matthews, Tuomas P. J. Knowles
Publicado en mBio (2019-02-01)

The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization

por Azad Farzadfard, Jannik Nedergaard Pedersen, Georg Meisl, Arun Kumar Somavarapu, Parvez Alam, Louise Goksøyr, Morten Agertoug Nielsen, Adam Frederik Sander, Tuomas P. J. Knowles, Jan Skov Pedersen, Daniel Erik Otzen
Publicado en Communications Biology (2022-02-01)

Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in <i>Pseudomonas</i> Strains by Directing Monomers to Off-Pathway Oligomers

por Zahra Najarzadeh, Hossein Mohammad-Beigi, Jannik Nedergaard Pedersen, Gunna Christiansen, Thorbjørn Vincent Sønderby, Seyed Abbas Shojaosadati, Dina Morshedi, Kristian Strømgaard, Georg Meisl, Duncan Sutherland, Jan Skov Pedersen, Daniel E. Otzen
Publicado en Biomolecules (2019-10-01)

The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity

por Catherine K. Xu, Marta Castellana-Cruz, Serene W. Chen, Zhen Du, Georg Meisl, Aviad Levin, Benedetta Mannini, Laura S. Itzhaki, Tuomas P. J. Knowles, Christopher M. Dobson, Nunilo Cremades, Janet R. Kumita
Publicado en Molecules (2022-02-01)

Super-resolution imaging unveils the self-replication of tau aggregates upon seeding

por Eleni Dimou, Taxiarchis Katsinelos, Georg Meisl, Benjamin J. Tuck, Sophie Keeling, Annabel E. Smith, Eric Hidari, Jeff Y.L. Lam, Melanie Burke, Sofia Lövestam, Rohan T. Ranasinghe, William A. McEwan, David Klenerman
Publicado en Cell Reports (2023-07-01)

α-Synuclein oligomers form by secondary nucleation

por Catherine K. Xu, Georg Meisl, Ewa A. Andrzejewska, Georg Krainer, Alexander J. Dear, Marta Castellana-Cruz, Soma Turi, Irina A. Edu, Giorgio Vivacqua, Raphaël P. B. Jacquat, William E. Arter, Maria Grazia Spillantini, Michele Vendruscolo, Sara Linse, Tuomas P. J. Knowles
Publicado en Nature Communications (2024-08-01)

Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants

por Marc Emmenegger, Sebastian Fiedler, Silvio D. Brugger, Sean R.A. Devenish, Alexey S. Morgunov, Alison Ilsley, Francesco Ricci, Anisa Y. Malik, Thomas Scheier, Leyla Batkitar, Lidia Madrigal, Marco Rossi, Georg Meisl, Andrew K. Lynn, Lanja Saleh, Arnold von Eckardstein, Tuomas P.J. Knowles, Adriano Aguzzi
Publicado en iScience (2022-08-01)

Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates

por Diana C. Rodriguez Camargo, Diana C. Rodriguez Camargo, Sean Chia, Sean Chia, Joseph Menzies, Benedetta Mannini, Benedetta Mannini, Georg Meisl, Martin Lundqvist, Christin Pohl, Katja Bernfur, Veronica Lattanzi, Johnny Habchi, Johnny Habchi, Samuel IA Cohen, Tuomas P. J Knowles, Tuomas P. J Knowles, Michele Vendruscolo, Sara Linse
Publicado en Frontiers in Molecular Biosciences (2021-11-01)

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

por Ryan Limbocker, Sean Chia, Francesco S. Ruggeri, Michele Perni, Roberta Cascella, Gabriella T. Heller, Georg Meisl, Benedetta Mannini, Johnny Habchi, Thomas C. T. Michaels, Pavan K. Challa, Minkoo Ahn, Samuel T. Casford, Nilumi Fernando, Catherine K. Xu, Nina D. Kloss, Samuel I. A. Cohen, Janet R. Kumita, Cristina Cecchi, Michael Zasloff, Sara Linse, Tuomas P. J. Knowles, Fabrizio Chiti, Michele Vendruscolo, Christopher M. Dobson
Publicado en Nature Communications (2019-01-01)

Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 the...

por Ashley Priddey, Michael Xin Hua Chen-Xu, Michael Xin Hua Chen-Xu, Daniel James Cooper, Daniel James Cooper, Serena MacMillan, Georg Meisl, Catherine K. Xu, Myra Hosmillo, Ian G. Goodfellow, Rafael Kollyfas, Rainer Doffinger, John R. Bradley, John R. Bradley, Irina I. Mohorianu, Rachel Jones, Rachel Jones, Tuomas P. J. Knowles, Tuomas P. J. Knowles, Rona Smith, Rona Smith, Vasilis Kosmoliaptsis, Vasilis Kosmoliaptsis
Publicado en Frontiers in Immunology (2024-01-01)

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

por Ryan Limbocker, Ryan Limbocker, Roxine Staats, Sean Chia, Francesco S. Ruggeri, Francesco S. Ruggeri, Francesco S. Ruggeri, Benedetta Mannini, Catherine K. Xu, Michele Perni, Roberta Cascella, Alessandra Bigi, Liam R. Sasser, Natalie R. Block, Aidan K. Wright, Ryan P. Kreiser, Edward T. Custy, Georg Meisl, Silvia Errico, Silvia Errico, Johnny Habchi, Patrick Flagmeier, Tadas Kartanas, Jared E. Hollows, Lam T. Nguyen, Kathleen LeForte, Denise Barbut, Janet R. Kumita, Cristina Cecchi, Michael Zasloff, Michael Zasloff, Tuomas P. J. Knowles, Tuomas P. J. Knowles, Christopher M. Dobson, Fabrizio Chiti, Michele Vendruscolo
Publicado en Frontiers in Neuroscience (2021-06-01)

Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region

por Marc Emmenegger, Elena De Cecco, David Lamparter, Raphaël P.B. Jacquat, Julien Riou, Dominik Menges, Tala Ballouz, Daniel Ebner, Matthias M. Schneider, Itzel Condado Morales, Berre Doğançay, Jingjing Guo, Anne Wiedmer, Julie Domange, Marigona Imeri, Rita Moos, Chryssa Zografou, Leyla Batkitar, Lidia Madrigal, Dezirae Schneider, Chiara Trevisan, Andres Gonzalez-Guerra, Alessandra Carrella, Irina L. Dubach, Catherine K. Xu, Georg Meisl, Vasilis Kosmoliaptsis, Tomas Malinauskas, Nicola Burgess-Brown, Ray Owens, Stephanie Hatch, Juthathip Mongkolsapaya, Gavin R. Screaton, Katharina Schubert, John D. Huck, Feimei Liu, Florence Pojer, Kelvin Lau, David Hacker, Elsbeth Probst-Müller, Carlo Cervia, Jakob Nilsson, Onur Boyman, Lanja Saleh, Katharina Spanaus, Arnold von Eckardstein, Dominik J. Schaer, Nenad Ban, Ching-Ju Tsai, Jacopo Marino, Gebhard F.X. Schertler, Nadine Ebert, Volker Thiel, Jochen Gottschalk, Beat M. Frey, Regina R. Reimann, Simone Hornemann, Aaron M. Ring, Tuomas P.J. Knowles, Milo A. Puhan, Christian L. Althaus, Ioannis Xenarios, David I. Stuart, Adriano Aguzzi
Publicado en iScience (2023-02-01)