Bibliotecas PUC-SP - Busca Integrada

Allosteric interactions between the myristate- and ATP-site of the Abl kinase.

av Roxana E Iacob, Jianming Zhang, Nathanael S Gray, John R Engen
I publikationen PLoS ONE (2011-01-01)

Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

av Julia R Kardon, Jamie A Moroco, John R Engen, Tania A Baker
I publikationen eLife (2020-02-01)

General structural features that regulate integrin affinity revealed by atypical αVβ8

av Jianchuan Wang, Yang Su, Roxana E. Iacob, John R. Engen, Timothy A. Springer
I publikationen Nature Communications (2019-12-01)

Native Capillary Electrophoresis–Mass Spectrometry of Near 1 MDa Non‐Covalent GroEL/GroES/Substrate Protein Complexes

av Anne‐Lise Marie, Florian Georgescauld, Kendall R. Johnson, Somak Ray, John R. Engen, Alexander R. Ivanov
I publikationen Advanced Science (2024-03-01)

Differential impact of BTK active site inhibitors on the conformational state of full-length BTK

av Raji E Joseph, Neha Amatya, D Bruce Fulton, John R Engen, Thomas E Wales, Amy Andreotti
I publikationen eLife (2020-11-01)

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX

av Daniel T. Cohen, Thomas E. Wales, Matthew W. McHenry, John R. Engen, Loren D. Walensky
I publikationen Cell Reports (2020-03-01)

The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core

av Noah B. Bloch, Thomas E. Wales, Michelle S. Prew, Hannah R. Levy, John R. Engen, Loren D. Walensky
I publikationen Nature Communications (2021-08-01)

Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.

av Jamie A Moroco, Jodi K Craigo, Roxana E Iacob, Thomas E Wales, John R Engen, Thomas E Smithgall
I publikationen PLoS ONE (2014-01-01)

Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker

av Klaus Bonazza, Roxana E Iacob, Nathan E Hudson, Jing Li, Chafen Lu, John R Engen, Timothy A Springer
I publikationen eLife (2022-05-01)

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

av David Yin-wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti
I publikationen eLife (2024-01-01)

Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.

av Nikita Chopra, Thomas E Wales, Raji E Joseph, Scott E Boyken, John R Engen, Robert L Jernigan, Amy H Andreotti
I publikationen PLoS Computational Biology (2016-03-01)

Fusion surface structure, function, and dynamics of gamete fusogen HAP2

av Juan Feng, Xianchi Dong, Jennifer Pinello, Jun Zhang, Chafen Lu, Roxana E Iacob, John R Engen, William J Snell, Timothy A Springer
I publikationen eLife (2018-10-01)

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

av Raji E Joseph, Thomas E Wales, Sandrine Jayne, Robert G Britton, D Bruce Fulton, John R Engen, Martin JS Dyer, Amy H Andreotti
I publikationen eLife (2024-12-01)

Structural mechanism of a drug-binding process involving a large conformational change of the protein target

av Pelin Ayaz, Agatha Lyczek, YiTing Paung, Victoria R. Mingione, Roxana E. Iacob, Parker W. de Waal, John R. Engen, Markus A. Seeliger, Yibing Shan, David E. Shaw
I publikationen Nature Communications (2023-04-01)

Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency

av Michelle S. Prew, Christina M. Camara, Thomas Botzanowski, Jamie A. Moroco, Noah B. Bloch, Hannah R. Levy, Hyuk-Soo Seo, Sirano Dhe-Paganon, Gregory H. Bird, Henry D. Herce, Micah A. Gygi, Silvia Escudero, Thomas E. Wales, John R. Engen, Loren D. Walensky
I publikationen Nature Communications (2022-06-01)

Allosteric control of Ubp6 and the proteasome via a bidirectional switch

av Ka Ying Sharon Hung, Sven Klumpe, Markus R. Eisele, Suzanne Elsasser, Geng Tian, Shuangwu Sun, Jamie A. Moroco, Tat Cheung Cheng, Tapan Joshi, Timo Seibel, Duco Van Dalen, Xin-Hua Feng, Ying Lu, Huib Ovaa, John R. Engen, Byung-Hoon Lee, Till Rudack, Eri Sakata, Daniel Finley
I publikationen Nature Communications (2022-02-01)

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6

av Nina Kerres, Steffen Steurer, Stefanie Schlager, Gerd Bader, Helmut Berger, Maureen Caligiuri, Christian Dank, John R. Engen, Peter Ettmayer, Bernhard Fischerauer, Gerlinde Flotzinger, Daniel Gerlach, Thomas Gerstberger, Teresa Gmaschitz, Peter Greb, Bingsong Han, Elizabeth Heyes, Roxana E. Iacob, Dirk Kessler, Heike Kölle, Lyne Lamarre, David R. Lancia, Simon Lucas, Moriz Mayer, Katharina Mayr, Nikolai Mischerikow, Katja Mück, Christoph Peinsipp, Oliver Petermann, Ulrich Reiser, Dorothea Rudolph, Klaus Rumpel, Carina Salomon, Dirk Scharn, Renate Schnitzer, Andreas Schrenk, Norbert Schweifer, Diane Thompson, Elisabeth Traxler, Roland Varecka, Tilman Voss, Alexander Weiss-Puxbaum, Sandra Winkler, Xiaozhang Zheng, Andreas Zoephel, Norbert Kraut, Darryl McConnell, Mark Pearson, Manfred Koegl
I publikationen Cell Reports (2017-09-01)